Structure information

CysLT2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

9IXX

SPECIES

Homo sapiens

RESOLUTION

3.150

PREFERRED CHAIN

R

REFERENCE

10.1073/PNAS.2417148122

PUBLICATION DATE

April 2, 2025

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
LTD<sub>4</sub> K37 1.31x31 TM1 polar (charge-assisted hydrogen bond)
LTD<sub>4</sub> S115 3.29x29 TM3 polar (hydrogen bond)
LTD<sub>4</sub> Y119 3.33x33 TM3 polar (hydrogen bond)
LTD<sub>4</sub> Y123 3.37x37 TM3 polar (hydrogen bond)
LTD<sub>4</sub> I166 4.53x53 TM4 Van der Waals
LTD<sub>4</sub> S169 4.56x56 TM4 polar (hydrogen bond)
LTD<sub>4</sub> S170 4.57x57 TM4 Van der Waals
LTD<sub>4</sub> L173 4.60x61 TM4 Van der Waals
LTD<sub>4</sub> L173 4.60x61 TM4 hydrophobic
LTD<sub>4</sub> L188 45.51x51 ECL2 Van der Waals
LTD<sub>4</sub> L188 45.51x51 ECL2 polar (hydrogen bond with backbone)
LTD<sub>4</sub> E189 45.52x52 ECL2 polar (hydrogen bond with backbone)
LTD<sub>4</sub> E189 45.52x52 ECL2 Van der Waals
LTD<sub>4</sub> L198 5.35x36 TM5 hydrophobic
LTD<sub>4</sub> L198 5.35x36 TM5 Van der Waals
LTD<sub>4</sub> M201 5.38x39 TM5 polar (hydrogen bond with backbone)
LTD<sub>4</sub> M201 5.38x39 TM5 Van der Waals
LTD<sub>4</sub> I204 5.41x42 TM5 Van der Waals
LTD<sub>4</sub> A205 5.42x43 TM5 Van der Waals
LTD<sub>4</sub> V208 5.45x46 TM5 Van der Waals
LTD<sub>4</sub> R267 6.55x55 TM6 polar (charge-assisted hydrogen bond)
LTD<sub>4</sub> L271 6.59x59 TM6 Van der Waals
LTD<sub>4</sub> H284 7.32x31 TM7 polar (hydrogen bond)
LTD<sub>4</sub> H284 7.32x31 TM7 Van der Waals
LTD<sub>4</sub> L287 7.35x34 TM7 Van der Waals
LTD<sub>4</sub> L287 7.35x34 TM7 hydrophobic

Ligands

LTD<sub>4</sub>

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Residue Diagrams

G N G L V G W F F I I L Y V I P F F E R 1 L N L A I S D L L F I S T L P F R A D Y 2 V T L F Y I S S Y M N V Y L S Y S M I R 3 A W I L C G I I W I L I M A S S I M L 4 Y C I S L T F F P L L C G V V L A I Y N M 5 I I I T L I I F L F C F L P Y H T L R T V 6 L P N F C A N A A A L A L T I V L A K 7
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ICL1 Y K K S ICL1ECL1 S N W I F ECL1ICL2 P F R L L H V T ICL2ECL2 G S E Q N G S V T S C L E L N L Y K ECL2ICL3 E V P E ICL3ECL3 K V G L C ECL3N-term M E R K F M S L Q P S I S V S E M E P N G T F S N N N S R N N-termC-term G H P Q K A K T K C V F P V S V W L R K E T R V C-term C T I E N F K R E F F P I V Y L I I F F W G V L G N G L S I Y V F L Q P T S V N V F M L N L A I S D L L F I S T L P F R A D Y Y L R G G D L A C R I M S Y S L Y V N M Y S S I Y F L T V L S V V R F L A M V H S I R S A W I L C G I I W I L I M A S S I M L L D S I A K L Q T M N Y I A L V V G C L L P F F T L S I C Y L L I I R V L L K V S G L R V S H R K A L T T I I I T L I I F F L C F L P Y H T L R T V H L T T W K D R L H K A L V I T L A L A A A N A C F N P L L Y Y F A G E N L K S F K D R A L R K
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Residue Table


GPCRdb(A)
GPCRdb(A)
CysLT2 receptor
TM1
1x31 1.31x31 K37
TM3
3x29 3.29x29 S115
3x33 3.33x33 Y119
3x37 3.37x37 Y123
TM4
4x53 4.53x53 I166
4x56 4.56x56 S169
4x57 4.57x57 S170
4x61 4.60x61 L173
ECL2
45x51 45.51x51 L188
45x52 45.52x52 E189
TM5
5x36 5.35x36 L198
5x39 5.38x39 M201
5x42 5.41x42 I204
5x43 5.42x43 A205
5x46 5.45x46 V208
TM6
6x55 6.55x55 R267
6x59 6.59x59 L271
TM7
7x31 7.32x31 H284
7x34 7.35x34 L287