Structure information

GPR4

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

9JCO

SPECIES

Homo sapiens

RESOLUTION

2.360

PREFERRED CHAIN

R

REFERENCE

PUBLICATION DATE

July 9, 2025

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Lysophosphatidylcholine (LPC) Y55 2.42x42 TM2 polar (hydrogen bond)
Lysophosphatidylcholine (LPC) A106 3.41x41 TM3 Van der Waals
Lysophosphatidylcholine (LPC) C109 3.44x44 TM3 Van der Waals
Lysophosphatidylcholine (LPC) C110 3.45x45 TM3 polar (hydrogen bond)
Lysophosphatidylcholine (LPC) C110 3.45x45 TM3 polar (hydrogen bond with backbone)
Lysophosphatidylcholine (LPC) V113 3.48x48 TM3 polar (hydrogen bond)
Lysophosphatidylcholine (LPC) V113 3.48x48 TM3 polar (hydrogen bond with backbone)
Lysophosphatidylcholine (LPC) D114 3.49x49 TM3 polar (hydrogen bond with backbone)
Lysophosphatidylcholine (LPC) D114 3.49x49 TM3 Van der Waals
Lysophosphatidylcholine (LPC) L117 3.52x52 TM3 polar (hydrogen bond)
Lysophosphatidylcholine (LPC) L128 ICL2 Van der Waals
Lysophosphatidylcholine (LPC) V137 4.45x45 TM4 polar (hydrogen bond)
Lysophosphatidylcholine (LPC) T144 4.52x52 TM4 Van der Waals
Lysophosphatidylcholine (LPC) E145 4.53x53 TM4 polar (charge-assisted hydrogen bond)
Lysophosphatidylcholine (LPC) V188 5.45x46 TM5 polar (hydrogen bond with backbone)
Lysophosphatidylcholine (LPC) V188 5.45x46 TM5 Van der Waals
Lysophosphatidylcholine (LPC) F192 5.49x49 TM5 Van der Waals

Ligands

Lysophosphatidylcholine (LPC)

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Residue Diagrams

C N T P L G V G I V F I Y L S P P F L H 1 M N L S I A D L L Y I C T L P L W V D Y 2 C C L F A I S I Y I N T Y F I F G F L K 3 A V A V S S V V W A T E L G A N S A P L 4 Y S L L M L A W P F L F G V F V R Y L N M 5 L S L I A I V L V C F A P Y H V L L L S 6 I P D A V C N L S T F A L S S H Y A S 7
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ICL1 R ICL1ECL1 D N W I H ECL1ICL2 P L R F A R L R ICL2ECL2 D E L F R D R Y N H T F C F E K F P M ECL2ICL3 S V S T ICL3ECL3 W D ECL3N-term M G N H T W E G C H V N-termC-term F L A S D K P Q E M A N A S L T L E T P L T S K R N S T A K A M T G S W A A T P P S Q G D Q V Q L K M L P P A Q C-term D S R V D H L F P P S L Y I F V I G V G L P T N C L A L W A A Y R Q V Q Q N E L G V Y L M N L S I A D L L Y I C T L P L W V D Y F L H H G P G S C K L F G F I F Y T N I Y I S I A F L C C I S V D R Y L A V A H R V K T A V A V S S V V W A T E L G A N S A P L F H E G W V A W M N L Y R V F V G F L F P W A L M L L S Y R G I L R A V R G E R Q E K A K I K R L A L S L I A I V L V C F A P Y H V L L L S R S A I Y L G R P C G F E E R V F S A Y H S S L A F T S L N C V A D P I L Y C L V N E G V A K L L R A R S D A L H N
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Residue Table


GPCRdb(A)
GPCRdb(A)
GPR4
TM2
2x42 2.42x42 Y55
TM3
3x41 3.41x41 A106
3x44 3.44x44 C109
3x45 3.45x45 C110
3x48 3.48x48 V113
3x49 3.49x49 D114
3x52 3.52x52 L117
TM4
4x45 4.45x45 V137
4x52 4.52x52 T144
4x53 4.53x53 E145
TM5
5x46 5.45x46 V188
5x49 5.49x49 F192