Structure information

GPR4

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

9JCP

SPECIES

Homo sapiens

RESOLUTION

2.550

PREFERRED CHAIN

R

REFERENCE

PUBLICATION DATE

July 9, 2025

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Lysophosphatidylcholine (LPC) Y55 2.42x42 TM2 polar (hydrogen bond)
Lysophosphatidylcholine (LPC) Y102 3.37x37 TM3 polar (hydrogen bond with backbone)
Lysophosphatidylcholine (LPC) Y102 3.37x37 TM3 Van der Waals
Lysophosphatidylcholine (LPC) A106 3.41x41 TM3 polar (charge-assisted hydrogen bond)
Lysophosphatidylcholine (LPC) C110 3.45x45 TM3 polar (hydrogen bond with backbone)
Lysophosphatidylcholine (LPC) C110 3.45x45 TM3 polar (hydrogen bond)
Lysophosphatidylcholine (LPC) C110 3.45x45 TM3 polar (hydrogen bond)
Lysophosphatidylcholine (LPC) V113 3.48x48 TM3 polar (hydrogen bond)
Lysophosphatidylcholine (LPC) D114 3.49x49 TM3 Van der Waals
Lysophosphatidylcholine (LPC) V137 4.45x45 TM4 polar (hydrogen bond)
Lysophosphatidylcholine (LPC) V141 4.49x49 TM4 Van der Waals
Lysophosphatidylcholine (LPC) E145 4.53x53 TM4 polar (charge-assisted hydrogen bond)
Lysophosphatidylcholine (LPC) V188 5.45x46 TM5 polar (hydrogen bond with backbone)
Lysophosphatidylcholine (LPC) V188 5.45x46 TM5 Van der Waals
Lysophosphatidylcholine (LPC) G189 5.46x461 TM5 polar (hydrogen bond with backbone)
Lysophosphatidylcholine (LPC) G189 5.46x461 TM5 polar (charge-assisted hydrogen bond)
Lysophosphatidylcholine (LPC) F192 5.49x49 TM5 polar (hydrogen bond)
Lysophosphatidylcholine (LPC) P193 5.50x50 TM5 Van der Waals
Lysophosphatidylcholine (LPC) P193 5.50x50 TM5 hydrophobic

Ligands

Lysophosphatidylcholine (LPC)

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Residue Diagrams

C N T P L G V G I V F I Y L S P P F L H 1 M N L S I A D L L Y I C T L P L W V D Y 2 C C L F A I S I Y I N T Y F I F G F L K 3 A V A V S S V V W A T E L G A N S A P L 4 Y S L L M L A W P F L F G V F V R Y L N M 5 L S L I A I V L V C F A P Y H V L L L S 6 I P D A V C N L S T F A L S S H Y A S 7
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ICL1 R ICL1ECL1 D N W I H ECL1ICL2 P L R F A R L R ICL2ECL2 D E L F R D R Y N H T F C F E K F P M ECL2ICL3 S V S T ICL3ECL3 W D ECL3N-term M G N H T W E G C H V N-termC-term F L A S D K P Q E M A N A S L T L E T P L T S K R N S T A K A M T G S W A A T P P S Q G D Q V Q L K M L P P A Q C-term D S R V D H L F P P S L Y I F V I G V G L P T N C L A L W A A Y R Q V Q Q N E L G V Y L M N L S I A D L L Y I C T L P L W V D Y F L H H G P G S C K L F G F I F Y T N I Y I S I A F L C C I S V D R Y L A V A H R V K T A V A V S S V V W A T E L G A N S A P L F H E G W V A W M N L Y R V F V G F L F P W A L M L L S Y R G I L R A V R G E R Q E K A K I K R L A L S L I A I V L V C F A P Y H V L L L S R S A I Y L G R P C G F E E R V F S A Y H S S L A F T S L N C V A D P I L Y C L V N E G V A K L L R A R S D A L H N
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Residue Table


GPCRdb(A)
GPCRdb(A)
GPR4
TM2
2x42 2.42x42 Y55
TM3
3x37 3.37x37 Y102
3x41 3.41x41 A106
3x45 3.45x45 C110
3x48 3.48x48 V113
3x49 3.49x49 D114
TM4
4x45 4.45x45 V137
4x49 4.49x49 V141
4x53 4.53x53 E145
TM5
5x46 5.45x46 V188
5x461 5.46x461 G189
5x49 5.49x49 F192
5x50 5.50x50 P193