Structure information

GPR4

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

9JFU

SPECIES

Homo sapiens

RESOLUTION

3.230

PREFERRED CHAIN

R

REFERENCE

PUBLICATION DATE

April 23, 2025

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
NE 52-QQ57 Y24 1.39x39 TM1 hydrophobic
NE 52-QQ57 L70 2.57x57 TM2 hydrophobic
NE 52-QQ57 W73 2.60x60 TM2 aromatic (face-to-face)
NE 52-QQ57 F77 2.64x64 TM2 hydrophobic
NE 52-QQ57 D81 ECL1 Van der Waals
NE 52-QQ57 D81 ECL1 polar (hydrogen bond with backbone)
NE 52-QQ57 C168 45.50x50 ECL2 Van der Waals
NE 52-QQ57 F169 45.51x51 ECL2 hydrophobic
NE 52-QQ57 F169 45.51x51 ECL2 Van der Waals
NE 52-QQ57 H381 7.36x35 TM7 aromatic (edge-to-face)
NE 52-QQ57 H381 7.36x35 TM7 Van der Waals
NE 52-QQ57 L384 7.39x38 TM7 Van der Waals
NE 52-QQ57 L384 7.39x38 TM7 hydrophobic

Ligands

NE 52-QQ57

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Residue Diagrams

C N T P L G V G I V F I Y L S P P F L H 1 M N L S I A D L L Y I C T L P L W V D Y 2 C C L F A I S I Y I N T Y F I F G F L K 3 A V A V S S V V W A T E L G A N S A P L 4 Y S L L M L A W P F L F G V F V R Y L N M 5 L S L I A I V L V C F A P Y H V L L L S 6 I P D A V C N L S T F A L S S H Y A S 7
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ICL1 R ICL1ECL1 D N W I H ECL1ICL2 P L R F A R L R ICL2ECL2 D E L F R D R Y N H T F C F E K F P M ECL2ICL3 S V S T ICL3ECL3 W D ECL3N-term M G N H T W E G C H V N-termC-term F L A S D K P Q E M A N A S L T L E T P L T S K R N S T A K A M T G S W A A T P P S Q G D Q V Q L K M L P P A Q C-term D S R V D H L F P P S L Y I F V I G V G L P T N C L A L W A A Y R Q V Q Q N E L G V Y L M N L S I A D L L Y I C T L P L W V D Y F L H H G P G S C K L F G F I F Y T N I Y I S I A F L C C I S V D R Y L A V A H R V K T A V A V S S V V W A T E L G A N S A P L F H E G W V A W M N L Y R V F V G F L F P W A L M L L S Y R G I L R A V R G E R Q E K A K I K R L A L S L I A I V L V C F A P Y H V L L L S R S A I Y L G R P C G F E E R V F S A Y H S S L A F T S L N C V A D P I L Y C L V N E G V A K L L R A R S D A L H N
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Residue Table


GPCRdb(A)
GPCRdb(A)
GPR4
TM1
1x39 1.39x39 Y24
TM2
2x57 2.57x57 L70
2x60 2.60x60 W73
2x64 2.64x64 F77
ECL2
45x50 45.50x50 C168
45x51 45.51x51 F169
TM7
7x35 7.36x35 H269
7x38 7.39x38 L272