Structure information

HCA3 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

9JID

SPECIES

Homo sapiens

RESOLUTION

2.780

PREFERRED CHAIN

A

REFERENCE

10.1016/J.CELREP.2024.114895

PUBLICATION DATE

Dec. 17, 2025

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
nicotinic acid Y86 ECL1 polar (hydrogen bond)
nicotinic acid Y86 ECL1 Van der Waals
nicotinic acid Y86 ECL1 aromatic (face-to-edge)
nicotinic acid L104 3.29x29 TM3 Van der Waals
nicotinic acid L104 3.29x29 TM3 hydrophobic
nicotinic acid F107 3.32x32 TM3 aromatic (face-to-face)
nicotinic acid F107 3.32x32 TM3 Van der Waals
nicotinic acid R111 3.36x36 TM3 polar (charge-assisted hydrogen bond)
nicotinic acid Y284 7.43x42 TM7 polar (hydrogen bond)
nicotinic acid Y284 7.43x42 TM7 Van der Waals

Ligands

nicotinic acid

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Residue Diagrams

G N G L L G F I F E L G L V P P L V K A 1 F N L A V A D F L L I I C L P F V M D Y 2 V T L F I I S G Q R N M A F M F L V L R 3 A A I I S C L L W G I T V G L T V H L L 4 S C F L I I G L P L F F E L L F M A E H W 5 M V V A I V F V I C F L P S V V V R I H 6 V P D L M S N M Y T F S L T I F F A L 7
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ICL1 L K S W ICL1ECL1 R S D W K F ECL1ICL2 P H H A L N K I ICL2ECL2 L L I Q N G T A N V C I S F S I C H T F ECL2ICL3 Q M D R H A ICL3ECL3 G T Q N C E ECL3N-term M N R H H L Q D H F L E I D K K N C C V F R N-termC-term R C L Q R K I T G E P D N N R S T S V E L T G D P N K T R G A P E A L I A N S G E P W S P S Y L G P T S N N H S K K G H C H Q E P A S L E K Q L G C C I E C-term D D F I A K V L P P V L G L E F I F G L L G N G L A L W I F C F H K S S R I F L F N L A V A D F L L I I C L P F V M D Y Y V R G D I P C R L V L F M F A M N R Q G S I I F L T V V A V D R Y F R V V H S N W T A A I I S C L L W G I T V G L T V H L L K K K R W H E A M F L L E F F L P L G I I L F C S A R I I W S L R Q R K I K R A I T F I M V V A I V F V I C F L P S V V V R I H I F W L L H T S V Y R S V D L A F F I T L S F T Y M N S M L D P V V Y Y F S S P S F S T F P N F L I N
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Residue Table


GPCRdb(A)
GPCRdb(A)
HCA3 receptor
TM3
3x29 3.29x29 L104
3x32 3.32x32 F107
3x36 3.36x36 R111
TM7
7x42 7.43x42 Y284