Structure information

EP2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

9JRT

SPECIES

Homo sapiens

RESOLUTION

3.280

PREFERRED CHAIN

A

REFERENCE

PUBLICATION DATE

Oct. 22, 2025

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
TG6-129 S28 1.39x39 TM1 polar (hydrogen bond)
TG6-129 S28 1.39x39 TM1 polar (hydrogen bond)
TG6-129 M31 1.42x42 TM1 Van der Waals
TG6-129 M31 1.42x42 TM1 hydrophobic
TG6-129 D78 2.50x50 TM2 Van der Waals
TG6-129 G81 2.53x53 TM2 Van der Waals
TG6-129 T82 2.54x54 TM2 Van der Waals
TG6-129 I85 2.57x57 TM2 Van der Waals
TG6-129 I85 2.57x57 TM2 hydrophobic
TG6-129 S86 2.58x58 TM2 polar (hydrogen bond)
TG6-129 V89 2.61x61 TM2 hydrophobic
TG6-129 V89 2.61x61 TM2 Van der Waals
TG6-129 Y93 ECL1 polar (hydrogen bond)
TG6-129 Y93 ECL1 polar (hydrogen bond)
TG6-129 F119 3.35x35 TM3 polar (hydrogen bond with backbone)
TG6-129 F119 3.35x35 TM3 Van der Waals
TG6-129 T123 3.39x39 TM3 Van der Waals
TG6-129 T185 ECL2 Van der Waals
TG6-129 W186 ECL2 aromatic (face-to-face)
TG6-129 W186 ECL2 polar (hydrogen bond)
TG6-129 W186 ECL2 Van der Waals
TG6-129 R382 7.40x39 TM7 Van der Waals
TG6-129 L384 7.42x41 TM7 Van der Waals
TG6-129 S385 7.43x42 TM7 Van der Waals
TG6-129 S388 7.46x46 TM7 polar (hydrogen bond)
TG6-129 S388 7.46x46 TM7 Van der Waals

Ligands

TG6-129

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Residue Diagrams

L N G L V G A S F M V S S I A P S 1 T E L V F T D L L G T C L I S P V V L A 2 A F L M L M T A L S F F T M A F A F Y T 3 G L A V L P V I Y A V S L L F C S L P L 4 S F N C A L V S V I L L L L L T A Y L Q 5 A I M T I T F A V C S L P F T I F A Y M 6 W P D I I S N I S L F R L A Q L D W 7
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ICL1 W R G D V G C S A G R R S S L ICL1ECL1 Q T L V A L A P E ECL1ICL2 P Y F Y Q R R V ICL2ECL2 Y G Q Y V Q Y C P G T W C F I R H G R ECL2ICL3 P S L G S G R G G P G A R R R G E ICL3ECL3 N E T S S R K E K ECL3N-term M G N A S N D S Q S E D C E T R Q W L P P G E N-termC-term R I S L R T Q D A T Q T S C S T Q S D A S K Q A D L C-term S P A I S S V M F S A G V L G N L I A L A L L A R R S L F H V L V T E L V F T D L L G T C L I S P V V L A S Y A R N S R A C T Y F A F A M T F F S L A T M L M L F A M A L E R Y L S I G H S R S G G L A V L P V I Y A V S L L F C S L P L L D T A Y L Q L Y A T L L L L L I V S V L A C N F S V I L N L I R M H R R S R R S R C G R V S M A E E T D H L I L L A I M T I T F A V C S L P F T I F A Y M W D L Q A L R F L S I N S I I D P W V F A I L R P P M R S V L R L V L C C
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Residue Table


GPCRdb(A)
GPCRdb(A)
EP2 receptor
TM1
1x39 1.39x39 S28
1x42 1.42x42 M31
TM2
2x50 2.50x50 D78
2x53 2.53x53 G81
2x54 2.54x54 T82
2x57 2.57x57 I85
2x58 2.58x58 S86
2x61 2.61x61 V89
TM3
3x35 3.35x35 F119
3x39 3.39x39 T123
TM7
7x39 7.40x39 R302
7x41 7.42x41 L304
7x42 7.43x42 S305
7x46 7.46x46 S308