Structure information

P2Y2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

9K0X

SPECIES

Homo sapiens

RESOLUTION

2.830

PREFERRED CHAIN

I

REFERENCE

10.1038/S41421-025-00797-X

PUBLICATION DATE

June 11, 2025

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
ATP Y23 N-term aromatic (face-to-face)
ATP F27 N-term aromatic (face-to-face)
ATP E29 N-term polar (charge-assisted hydrogen bond)
ATP K32 1.31x31 TM1 Van der Waals
ATP Y93 2.64x64 TM2 polar (hydrogen bond)
ATP R110 3.29x29 TM3 polar (charge-assisted hydrogen bond)
ATP H184 45.51x51 ECL2 Van der Waals
ATP D185 45.52x52 ECL2 polar (hydrogen bond with backbone)
ATP D185 45.52x52 ECL2 Van der Waals
ATP T186 ECL2 polar (hydrogen bond)
ATP T186 ECL2 polar (hydrogen bond)
ATP T186 ECL2 polar (hydrogen bond with backbone)
ATP Y268 6.58x58 TM6 polar (hydrogen bond)
ATP Y268 6.58x58 TM6 Van der Waals
ATP R272 ECL3 polar (charge-assisted hydrogen bond)
ATP K289 7.36x35 TM7 polar (charge-assisted hydrogen bond)
ATP R292 7.39x38 TM7 polar (charge-assisted hydrogen bond)

Ligands

ATP

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Residue Diagrams

A N L C L G P V C V V G Y S V P L L V Y 1 F H L A V S D A L Y A A S L P L L V Y Y 2 C T L F L I S C Y L N T Y F L F R V L K 3 A R R V A G A V W V L V L A C Q A P V L 4 Y C V L I V A F P V A F L L G L M V S S Y 5 I A V V L A V F L A C F L P F H V T R T L 6 V P D L C S N A S A L P R T V K Y A M 7
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ICL1 L K T W ICL1ECL1 G D H W P F ECL1ICL2 P L R S L R W G ICL2ECL2 T T S A R G G R V T C H D T S A P E L ECL2ICL3 Y G T ICL3ECL3 R S L D L ECL3N-term M A A D L G P W N D T I N G T W D G D E L G Y R C R F N E D N-termC-term P T G P S P A T P A R R R L G L R R S D R T D M Q R I E D V L G S S E D S R R T E S T P A G S E N T K D I R L C-term F K Y V L L P V S Y G V V C V P G L C L N A V A L Y I F L C R N A S T T Y M F H L A V S D A L Y A A S L P L L V Y Y Y A R S T V L C K L V R F L F Y T N L Y C S I L F L T C I S V H R C L G V L R R A R Y A R R V A G A V W V L V L A C Q A P V L Y F V F S R F V A Y S S V M L G L L F A V P F A V I L V C Y V L M A R R L L K P A S G G L P R A K R K S V R T I A V V L A V F A L C F L P F H V T R T L Y Y S F S C H T L N A I N M A Y K V T R P L A S A N S C L D P V L Y F L A G Q R A R D L V R F A K P
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Residue Table


GPCRdb(A)
GPCRdb(A)
P2Y2 receptor
TM1
1x31 1.31x31 K32
TM2
2x64 2.64x64 Y93
TM3
3x29 3.29x29 R110
ECL2
45x51 45.51x51 H184
45x52 45.52x52 D185
TM6
6x58 6.58x58 Y268
TM7
7x35 7.36x35 K289
7x38 7.39x38 R292