Structure information

TAS2R16

PROTEIN CLASS

Class T2 (Taste 2)

PDB CODE

9KPE

SPECIES

Homo sapiens

RESOLUTION

3.350

PREFERRED CHAIN

R

REFERENCE

10.1016/J.CELREP.2025.115604

PUBLICATION DATE

April 2, 2025

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
salicin N66 2.60x60 TM2 polar (hydrogen bond)
salicin N66 2.60x60 TM2 Van der Waals
salicin T82 3.29x29 TM3 Van der Waals
salicin W85 3.32x32 TM3 Van der Waals
salicin W85 3.32x32 TM3 hydrophobic
salicin E86 3.33x33 TM3 Van der Waals
salicin T246 6.55x55 TM6 Van der Waals
salicin I247 6.56x56 TM6 hydrophobic
salicin I247 6.56x56 TM6 Van der Waals
salicin E262 7.39x38 TM7 polar (charge-assisted hydrogen bond)
salicin V265 7.42x41 TM7 Van der Waals
salicin Y266 7.43x42 TM7 polar (hydrogen bond)
salicin Y266 7.43x42 TM7 Van der Waals

Ligands

salicin

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Residue Diagrams

S S Q V I I T L S E L V Y I I M F F V T 1 I S L G I S R F C L Q W A S M L N N F C 2 L S N L W F T L I N F F E W T I T L N C 3 F P W I L L G S L M I T C V T I I P S A 4 T S A L F L I F P I V L A V T H A Q F Q 5 L A V L F I V F T S Y F L T I L I T I I 6 T S H M L I F A Y V F A E W V W L W C 7
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ICL1 R L ICL1ECL1 L N Y ECL1ICL2 S F T H H I F L W L R W ICL2ECL2 I Q I Q L L T M E H L P R N S T V T D K L E N F H Q Y ECL2ICL3 C ICL3ECL3 D K ECL3N-term M I N-term P I Q L T V F F M I I Y V L E S L T I I V Q S S L I V A V L G R E W L Q V R M P V D M I L I S L G I S R F C L Q W A S M L N N F C S Y F N V L C N L T I T W E F F N I L T F W L N S L L T V F Y C I K V S R I L R L F P W I L L G S L M I T C V T I I P S A I G N Y Q F Q A H T V A L V I P F I L F L A S T I F L M A S L T K Q I Q H H S T G H N P S M K A R F T A L R S L A V L F I V F T S Y F L T I L I T I I G T L F R C W L W V W E A F V Y A F I L M H S T S L M L S S P T L K G L K R I K C
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Residue Table


GPCRdb(A)
GPCRdb(A)
TAS2R16
TM2
2x60 2.60x60 N66
TM3
3x29 3.29x29 T82
3x32 3.32x32 W85
3x33 3.33x33 E86
TM6
6x55 6.55x55 T246
6x56 6.56x56 I247
TM7
7x38 7.39x38 E262
7x41 7.42x41 V265
7x42 7.43x42 Y266