Structure information

TAS2R16

PROTEIN CLASS

Class T2 (Taste 2)

PDB CODE

9KPF

SPECIES

Homo sapiens

RESOLUTION

3.150

PREFERRED CHAIN

R

REFERENCE

10.1016/J.CELREP.2025.115604

PUBLICATION DATE

April 2, 2025

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
salicin S63 2.57x57 TM2 polar (hydrogen bond)
salicin N67 2.61x61 TM2 Van der Waals
salicin W85 3.32x32 TM3 Van der Waals
salicin W85 3.32x32 TM3 aromatic (face-to-edge)
salicin H181 5.43x44 TM5 Van der Waals
salicin H181 5.43x44 TM5 aromatic (face-to-edge)
salicin T246 6.55x55 TM6 Van der Waals
salicin I247 6.56x56 TM6 hydrophobic
salicin I247 6.56x56 TM6 Van der Waals
salicin K254 ECL3 Van der Waals
salicin W261 7.38x37 TM7 Van der Waals
salicin E262 7.39x38 TM7 polar (charge-assisted hydrogen bond)
salicin Y266 7.43x42 TM7 Van der Waals

Ligands

salicin

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Residue Diagrams

S S Q V I I T L S E L V Y I I M F F V T 1 I S L G I S R F C L Q W A S M L N N F C 2 L S N L W F T L I N F F E W T I T L N C 3 F P W I L L G S L M I T C V T I I P S A 4 T S A L F L I F P I V L A V T H A Q F Q 5 L A V L F I V F T S Y F L T I L I T I I 6 T S H M L I F A Y V F A E W V W L W C 7
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ICL1 R L ICL1ECL1 L N Y ECL1ICL2 S F T H H I F L W L R W ICL2ECL2 I Q I Q L L T M E H L P R N S T V T D K L E N F H Q Y ECL2ICL3 C ICL3ECL3 D K ECL3N-term M I N-term P I Q L T V F F M I I Y V L E S L T I I V Q S S L I V A V L G R E W L Q V R M P V D M I L I S L G I S R F C L Q W A S M L N N F C S Y F N V L C N L T I T W E F F N I L T F W L N S L L T V F Y C I K V S R I L R L F P W I L L G S L M I T C V T I I P S A I G N Y Q F Q A H T V A L V I P F I L F L A S T I F L M A S L T K Q I Q H H S T G H N P S M K A R F T A L R S L A V L F I V F T S Y F L T I L I T I I G T L F R C W L W V W E A F V Y A F I L M H S T S L M L S S P T L K G L K R I K C
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Residue Table


GPCRdb(A)
GPCRdb(A)
TAS2R16
TM2
2x57 2.57x57 S63
2x61 2.61x61 N67
TM3
3x32 3.32x32 W85
TM5
5x44 5.43x44 H181
TM6
6x55 6.55x55 T246
6x56 6.56x56 I247
TM7
7x37 7.38x37 W261
7x38 7.39x38 E262
7x42 7.43x42 Y266