Structure information

5-HT2A receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

9LLB

SPECIES

Homo sapiens

RESOLUTION

2.980

PREFERRED CHAIN

R

REFERENCE

PUBLICATION DATE

Jan. 14, 2026

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
DOI-NBOMe D155 3.32x32 TM3 polar (charge-assisted hydrogen bond)
DOI-NBOMe V156 3.33x33 TM3 Van der Waals
DOI-NBOMe V156 3.33x33 TM3 hydrophobic
DOI-NBOMe S159 3.36x36 TM3 Van der Waals
DOI-NBOMe S159 3.36x36 TM3 polar (hydrogen bond)
DOI-NBOMe V235 5.39x40 TM5 Van der Waals
DOI-NBOMe G238 5.42x43 TM5 Van der Waals
DOI-NBOMe S239 5.43x44 TM5 Van der Waals
DOI-NBOMe W336 6.48x48 TM6 hydrophobic
DOI-NBOMe W336 6.48x48 TM6 Van der Waals
DOI-NBOMe F339 6.51x51 TM6 Van der Waals
DOI-NBOMe F339 6.51x51 TM6 aromatic (face-to-edge)
DOI-NBOMe F340 6.52x52 TM6 hydrophobic
DOI-NBOMe F340 6.52x52 TM6 Van der Waals
DOI-NBOMe N343 6.55x55 TM6 Van der Waals
DOI-NBOMe G369 7.42x41 TM7 Van der Waals
DOI-NBOMe Y370 7.43x42 TM7 Van der Waals

Ligands

DOI-NBOMe

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Residue Diagrams

I N G A I T L I I V V A T L L A S W N K 1 M S L A I A D M L L G L F V M P V S M L T 2 A C L H M I S A T S F L V D L Y I W V A 3 A F L K I I A V W T I S V G I S M P I 4 Y T I V M I T L P I F F S V F S G I L V F 5 G I V F F L F V V M W C P F F I T N I M 6 L P N V A S S L Y G I W V F V N L L A 7
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ICL1 K K L Q ICL1ECL1 Y R W P L ECL1ICL2 P I H H S R F N ICL2ECL2 D S K V F K E G S C L L A ECL2ICL3 G T R A K L A S F S F L P Q S S L S S E K L F Q R S I H R E P G S Y T G R R T ICL3ECL3 K E S C ECL3N-term M D I L C E E N T S L S S T T N S L M Q L N D D T R L Y S N D F N S G E A N T S D A F N W T V D S E N R T N L S C E G C L S P S C L S L N-termC-term Q Y K E N K K P L Q L I L V N T I P A L A Y K S S Q L Q M G Q K K N S K Q D A K T T D N D C S M V A L G K Q H S E E A S K D N S D G V N E K V S C V C-term L H L Q E K N W S A L L T A V V I I L T I A G N I L V I M A V S L E N A T N Y F L M S L A I A D M L L G F L V M P V S M L T I L Y G P S K L C A V W I Y L D V L F S T A S I M H L C A I S L D R Y V A I Q N S R T K A F L K I I A V W T I S V G I S M P I P V F G L Q D D D N F V L I G S F V S F F I P L T I M V I T Y F L T I K S L Q K E A T L C V S D L M Q S I S N E Q K A C K V L G I V F F L F V V M W C P F F I T N I M A V I C N E D V I G A L L N V F V W I G Y L S S A V N P L V Y T L F N K T F S R Y R S A Y I Q C
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Residue Table


GPCRdb(A)
GPCRdb(A)
5-HT2A receptor
TM3
3x32 3.32x32 D155
3x33 3.33x33 V156
3x36 3.36x36 S159
TM5
5x40 5.39x40 V235
5x43 5.42x43 G238
5x44 5.43x44 S239
TM6
6x48 6.48x48 W336
6x51 6.51x51 F339
6x52 6.52x52 F340
6x55 6.55x55 N343
TM7
7x41 7.42x41 G369
7x42 7.43x42 Y370