Structure information

apelin receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

9LQY

SPECIES

Homo sapiens

RESOLUTION

2.400

PREFERRED CHAIN

A

REFERENCE

PUBLICATION DATE

Feb. 4, 2026

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
azelaprag W85 2.60x60 TM2 aromatic (face-to-edge)
azelaprag I109 3.32x32 TM3 hydrophobic
azelaprag F110 3.33x33 TM3 hydrophobic
azelaprag R168 4.64x65 TM4 polar (charge-assisted hydrogen bond)
azelaprag W261 6.48x48 TM6 Van der Waals
azelaprag W261 6.48x48 TM6 hydrophobic
azelaprag Y264 6.51x51 TM6 Van der Waals
azelaprag Y264 6.51x51 TM6 hydrophobic
azelaprag V267 6.54x54 TM6 Van der Waals
azelaprag K268 6.55x55 TM6 polar (charge-assisted hydrogen bond)
azelaprag Y271 6.58x58 TM6 aromatic (face-to-face)
azelaprag Y271 6.58x58 TM6 Van der Waals
azelaprag M288 7.32x31 TM7 Van der Waals
azelaprag F291 7.35x34 TM7 aromatic (face-to-face)
azelaprag F291 7.35x34 TM7 Van der Waals
azelaprag T295 7.39x38 TM7 Van der Waals
azelaprag Y299 7.43x42 TM7 polar (hydrogen bond)
azelaprag Y299 7.43x42 TM7 Van der Waals

Ligands

azelaprag

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Residue Diagrams

G N G T T G L L F V L M Y I A P I L A 1 A S L A V A D L T F V V T L P L W A T Y 2 G T L C F V S A Y M N V F I L Y S S L K 3 G A V A T A V L W V L A A L L A M P V 4 Y C T L M I T F P V V F G V T T S S V G L 5 V V L V V T F A L C W M P Y H L V K T L 6 F P N L C S N V Y S I C T C Y P F I N 7
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ICL1 S R E K R ICL1ECL1 Y D W P F ECL1ICL2 P V A N A R L R ICL2ECL2 T T G D L E N T T K V Q C Y M D Y S M V A T V S ECL2ICL3 R K E ICL3ECL3 L H W ECL3N-term M E E G G D F D N Y Y G A D N Q S E C E Y T D W K S S G N-termC-term Q S R C A G T S H S S S G E K S A S Y S S G H S Q G P G P N M G K G G E Q M H E K S I P Y S Q E T L V V D C-term A L I P A I Y M L V F L L G T T G N G L V L W T V F R S R S A D I F I A S L A V A D L T F V V T L P L W A T Y T Y R D G T F F C K L S S Y L I F V N M Y A S V F C L T G L S F D R Y L A I V R L R V S G A V A T A V L W V L A A L L A M P V M V L R S E W A W E V G L G V S S T T V G F V V P F T I M L T C Y F F I A Q T I A G H F R I E G L R K R R R L L S I I V V L V V T F A L C W M P Y H L V K T L Y M L G S L P C D F D L F L M N I F P Y C T C I S Y V N S C L N P F L Y A F F D P R C T S G F R Q A M L C C
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Residue Table


GPCRdb(A)
GPCRdb(A)
apelin receptor
TM2
2x60 2.60x60 W85
TM3
3x32 3.32x32 I109
3x33 3.33x33 F110
TM4
4x65 4.64x65 R168
TM6
6x48 6.48x48 W261
6x51 6.51x51 Y264
6x54 6.54x54 V267
6x55 6.55x55 K268
6x58 6.58x58 Y271
TM7
7x31 7.32x31 M288
7x34 7.35x34 F291
7x38 7.39x38 T295
7x42 7.43x42 Y299