Structure information

apelin receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

9LR3

SPECIES

Homo sapiens

RESOLUTION

2.800

PREFERRED CHAIN

R

REFERENCE

PUBLICATION DATE

Feb. 4, 2026

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
azelaprag Y35 1.39x39 TM1 hydrophobic
azelaprag W85 2.60x60 TM2 aromatic (face-to-edge)
azelaprag I109 3.32x32 TM3 hydrophobic
azelaprag F110 3.33x33 TM3 hydrophobic
azelaprag Y264 6.51x51 TM6 hydrophobic
azelaprag Y271 6.58x58 TM6 aromatic (face-to-face)
azelaprag F291 7.35x34 TM7 aromatic (edge-to-face)
azelaprag Y299 7.43x42 TM7 aromatic (face-to-edge)
azelaprag Y299 7.43x42 TM7 polar (hydrogen bond)
azelaprag Y299 7.43x42 TM7 Van der Waals

Ligands

azelaprag

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Residue Diagrams

G N G T T G L L F V L M Y I A P I L A 1 A S L A V A D L T F V V T L P L W A T Y 2 G T L C F V S A Y M N V F I L Y S S L K 3 G A V A T A V L W V L A A L L A M P V 4 Y C T L M I T F P V V F G V T T S S V G L 5 V V L V V T F A L C W M P Y H L V K T L 6 F P N L C S N V Y S I C T C Y P F I N 7
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ICL1 S R E K R ICL1ECL1 Y D W P F ECL1ICL2 P V A N A R L R ICL2ECL2 T T G D L E N T T K V Q C Y M D Y S M V A T V S ECL2ICL3 R K E ICL3ECL3 L H W ECL3N-term M E E G G D F D N Y Y G A D N Q S E C E Y T D W K S S G N-termC-term Q S R C A G T S H S S S G E K S A S Y S S G H S Q G P G P N M G K G G E Q M H E K S I P Y S Q E T L V V D C-term A L I P A I Y M L V F L L G T T G N G L V L W T V F R S R S A D I F I A S L A V A D L T F V V T L P L W A T Y T Y R D G T F F C K L S S Y L I F V N M Y A S V F C L T G L S F D R Y L A I V R L R V S G A V A T A V L W V L A A L L A M P V M V L R S E W A W E V G L G V S S T T V G F V V P F T I M L T C Y F F I A Q T I A G H F R I E G L R K R R R L L S I I V V L V V T F A L C W M P Y H L V K T L Y M L G S L P C D F D L F L M N I F P Y C T C I S Y V N S C L N P F L Y A F F D P R C T S G F R Q A M L C C
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Residue Table


GPCRdb(A)
GPCRdb(A)
apelin receptor
TM1
1x39 1.39x39 Y35
TM2
2x60 2.60x60 W85
TM3
3x32 3.32x32 I109
3x33 3.33x33 F110
TM6
6x51 6.51x51 Y264
6x58 6.58x58 Y271
TM7
7x34 7.35x34 F291
7x42 7.43x42 Y299