Structure information

MRGPRX4

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

9LRS

SPECIES

Homo sapiens

RESOLUTION

2.830

PREFERRED CHAIN

R

REFERENCE

PUBLICATION DATE

Feb. 4, 2026

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
PSB-18061 R82 2.60x60 TM2 polar (charge-assisted hydrogen bond)
PSB-18061 R86 2.64x64 TM2 Van der Waals
PSB-18061 H92 3.22x22 TM3 Van der Waals
PSB-18061 R95 3.25x25 TM3 polar (charge-assisted hydrogen bond)
PSB-18061 K96 3.26x26 TM3 Van der Waals
PSB-18061 V99 3.29x29 TM3 Van der Waals
PSB-18061 W158 ECL2 hydrophobic
PSB-18061 W158 ECL2 Van der Waals
PSB-18061 I239 ECL3 hydrophobic
PSB-18061 Y240 ECL3 polar (hydrogen bond)
PSB-18061 L246 ECL3 Van der Waals
PSB-18061 L246 ECL3 hydrophobic
PSB-18061 E247 ECL3 Van der Waals
PSB-18061 Y250 7.31x30 TM7 aromatic (face-to-face)
PSB-18061 Y250 7.31x30 TM7 polar (hydrogen bond)
PSB-18061 Y250 7.31x30 TM7 polar (hydrogen bond)
PSB-18061 Y254 7.35x34 TM7 aromatic (face-to-edge)
PSB-18061 Y254 7.35x34 TM7 Van der Waals
PSB-18061 Y254 7.35x34 TM7 polar (hydrogen bond)

Ligands

PSB-18061

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Residue Diagrams

A N G T L G V L S I I C T L V T F S L T 1 L N L A A A D F L F L S F Q I I R L P L 2 A S L M S L G T F Y P F T M V S V L I K 3 S A V V C V L L W G L S L L F S M L E W 4 S S V C L V V C L F I L W A V P I F D S 5 L L T V L V F L L C G L P F G I L G A L 6 I P N A S S N L S S L S M C V L Y V H 7
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ICL1 R R ICL1ECL1 I N I ECL1ICL2 P I W Y R C R R P T ICL2ECL2 D F L F S G A ECL2ICL3 G S R K M ICL3ECL3 I Y R M H L N L E ECL3N-term M D P T V P V F G T K L T P I N G R E E T P C Y N N-termC-term Q R Q N R Q N L K L V L Q R A L Q D K P E V D K G E G Q L P E E S L E L S G S R L G P C-term Q T L S F T V L T C I I S L V G L T G N A V V L W L L G Y R M N A V S I Y I L N L A A A D F L F L S F Q I I R L P L R L S H L I R K I L V S V M T F P Y F T G L S M L S A I S T E R C L S V L W H L S A V V C V L L W G L S L L F S M L E W R F C D S S W C E T S D F I P V A W L I F L C V V L C V S S L V L L V R I L C P L T R L Y V T I L L T V L V F L L C G L P F G I L G A L V L Y C H V Y L V C M S L S S L N S S A N P I I Y F F V G S F R
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Residue Table


GPCRdb(A)
GPCRdb(A)
MRGPRX4
TM2
2x60 2.60x60 R82
2x64 2.64x64 R86
TM3
3x22 3.22x22 H92
3x25 3.25x25 R95
3x26 3.26x26 K96
3x29 3.29x29 V99
TM7
7x30 7.31x30 Y250
7x34 7.35x34 Y254