Structure information

NPFF1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

9M0R

SPECIES

Homo sapiens

RESOLUTION

2.470

PREFERRED CHAIN

R

REFERENCE

10.1016/J.CELREP.2025.116160

PUBLICATION DATE

July 23, 2025

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Neuropeptide VF V127 3.36x36 TM3 hydrophobic
Neuropeptide VF W204 45.51x51 ECL2 hydrophobic
Neuropeptide VF T217 5.39x40 TM5 Van der Waals
Neuropeptide VF T217 5.39x40 TM5 polar (hydrogen bond)
Neuropeptide VF W287 6.52x52 TM6 Van der Waals
Neuropeptide VF W287 6.52x52 TM6 hydrophobic
Neuropeptide VF L290 6.55x55 TM6 hydrophobic
Neuropeptide VF L290 6.55x55 TM6 Van der Waals
Neuropeptide VF T307 7.31x30 TM7 Van der Waals
Neuropeptide VF F311 7.35x34 TM7 hydrophobic
Neuropeptide VF F311 7.35x34 TM7 Van der Waals
Neuropeptide VF H315 7.39x38 TM7 polar (hydrogen bond)
Neuropeptide VF H315 7.39x38 TM7 Van der Waals
Neuropeptide VF F319 7.43x42 TM7 Van der Waals

Ligands

Neuropeptide VF

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Residue Diagrams

T N G V M C L L F I L A Y A V I F M A A 1 L N L A V S D L L V G F I C M P T T L V D 2 A V L T F V S A S V S M G Q V L G S M K 3 A L V T I A V I W A L A L L I M C P S 4 Y M V V I L A L P A L Y I H S F L V T T Y 5 V M V A L F F T L S W L P L W A L L L L 6 I P N A S S N F F A L W H A F P F A Y 7
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ICL1 R H M H ICL1ECL1 G W P F ECL1ICL2 P F R E K L ICL2ECL2 T V T R E E H H F M V D A R N R S Y P L Y S C W E A W P E K ECL2ICL3 G G E E A ICL3ECL3 Q L S A P Q L ECL3N-term M E G E P S Q P P N S S W P L S Q N G T N T E A T P A T N L T F S S Y Y Q H T S P V N-termC-term P R P S G S H K E A Y S E R P G G L L H R R V F V V V R P S D S G L P S E S G P S S G A P R P G R L P L R N G R V A H H G L P R E G P G C S H L P L T I P A W D I C-term A A M F I V A Y A L I F L L C M V G N T L V C F I V L K N T V T N M F I L N L A V S D L L V G I F C M P T T L V D N L I T D N A T C K M S G L V Q G M S V S A S V F T L V A I A V E R F R C I V H T L R K A L V T I A V I W A L A L L I M C P S A V T L G M R R V Y T T V L F S H I Y L A P L A L I V V M Y A R I A R K L C Q A P G P A P A D P R A S R R R A R V V H M L V M V A L F F T L S W L P L W A L L L L I D Y G H L V T V Y A F P F A H W L A F F N S S A N P I I Y G Y F N E N F Q A R L C F R R G A F R A
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Residue Table


GPCRdb(A)
GPCRdb(A)
NPFF1 receptor
TM3
3x36 3.36x36 V127
ECL2
45x51 45.51x51 W204
TM5
5x40 5.39x40 T217
TM6
6x52 6.52x52 W287
6x55 6.55x55 L290
TM7
7x30 7.31x30 T307
7x34 7.35x34 F311
7x38 7.39x38 H315
7x42 7.43x42 F319