Structure information

GPR3

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

9M8P

SPECIES

Homo sapiens

RESOLUTION

3.420

PREFERRED CHAIN

A

REFERENCE

PUBLICATION DATE

Sept. 24, 2025

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
N-oleoylethanolamide H96 2.60x60 TM2 polar (hydrogen bond)
N-oleoylethanolamide V113 3.29x29 TM3 Van der Waals
N-oleoylethanolamide L116 3.32x32 TM3 hydrophobic
N-oleoylethanolamide L116 3.32x32 TM3 Van der Waals
N-oleoylethanolamide F120 3.36x36 TM3 hydrophobic
N-oleoylethanolamide F120 3.36x36 TM3 Van der Waals
N-oleoylethanolamide T121 3.37x37 TM3 Van der Waals
N-oleoylethanolamide I124 3.40x40 TM3 Van der Waals
N-oleoylethanolamide I124 3.40x40 TM3 hydrophobic
N-oleoylethanolamide V187 ECL2 hydrophobic
N-oleoylethanolamide L198 5.43x43 TM5 hydrophobic
N-oleoylethanolamide L198 5.43x43 TM5 Van der Waals
N-oleoylethanolamide F202 5.47x47 TM5 Van der Waals
N-oleoylethanolamide F202 5.47x47 TM5 hydrophobic
N-oleoylethanolamide V205 5.50x50 TM5 Van der Waals
AF64394 Q211 5.56x56 TM5 polar (hydrogen bond)
AF64394 Q211 5.56x56 TM5 polar (hydrogen bond)
AF64394 Q211 5.56x56 TM5 polar (hydrogen bond)
AF64394 A214 5.59x59 TM5 Van der Waals
AF64394 Q215 5.60x60 TM5 Van der Waals
AF64394 R218 5.63x63 TM5 polar (charge-assisted hydrogen bond)
N-oleoylethanolamide W260 6.48x48 TM6 Van der Waals
N-oleoylethanolamide W260 6.48x48 TM6 hydrophobic
N-oleoylethanolamide F263 6.51x51 TM6 hydrophobic
N-oleoylethanolamide F263 6.51x51 TM6 Van der Waals
N-oleoylethanolamide L283 7.39x38 TM7 Van der Waals
N-oleoylethanolamide L283 7.39x38 TM7 hydrophobic

Ligands

N-oleoylethanolamide

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AF64394

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Residue Diagrams

A N E C S V L T G S I C L V V D W A K 1 G S L A V A D L L A G L G L V L H F A A 2 A L L S G I S A T F A M A L V G V L V L 3 T Y V M L A L V W G G A L G L G L L P 4 Y L Q L M I G F V M F F A I A L V V L H 5 A V V L G A F A A C W L P F T V Y C L L 6 I P N I M S N Y T A P L L T L Y T Y L 7
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ICL1 P A F R ICL1ECL1 C I G ECL1ICL2 A L T Y Y ICL2ECL2 V L A W N C L D G L T T C G V V Y P L ECL2ICL3 H L ICL3ECL3 D A H S ECL3N-term M M W G A G S P L A W L S A G S G N V N V S S V G P A E G P T G P A A P L P S P N-termC-term C C S S S K I P F R S R S P S D V C-term K A W D V V L C I S G T L V S C E N A L V V A I I V G T A P M F L L V G S L A V A D L L A G L G L V L H F A A V F S A E M S L V L V G V L A M A F T A S I G S L L A I T V D R Y L S L Y N S E T T V T R T Y V M L A L V W G G A L G L G L L P S K N H L V V L A I A F F M V F G I M L Q L Y A Q I C R I V C R H A Q Q I A L Q R L P A S H Y V A T R K G I A T L A V V L G A F A A C W L P F T V Y C L L G P P L Y T Y L T L L P A T Y N S M I N P I I Y A F R N Q D L W A V Q K V V C C
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Residue Table


GPCRdb(A)
GPCRdb(A)
GPR3
TM2
2x60 2.60x60 H96
TM3
3x29 3.29x29 V113
3x32 3.32x32 L116
3x36 3.36x36 F120
3x37 3.37x37 T121
3x40 3.40x40 I124
TM5
5x43 5.43x43 L198
5x47 5.47x47 F202
5x50 5.50x50 V205
5x56 5.56x56 Q211
5x59 5.59x59 A214
5x60 5.60x60 Q215
5x63 5.63x63 R218
TM6
6x48 6.48x48 W260
6x51 6.51x51 F263
TM7
7x38 7.39x38 L283