Structure information

NTS1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

9P88

SPECIES

Homo sapiens

RESOLUTION

2.900

PREFERRED CHAIN

R

REFERENCE

10.1038/S41586-026-10120-7

PUBLICATION DATE

March 25, 2026

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
NTS8–13 S52 N-term Van der Waals
NTS8–13 S52 N-term polar (hydrogen bond with backbone)
NTS8–13 E53 N-term Van der Waals
NTS8–13 E53 N-term polar (hydrogen bond with backbone)
NTS8–13 L54 N-term Van der Waals
NTS8–13 L54 N-term polar (hydrogen bond with backbone)
NTS8–13 D55 N-term Van der Waals
NTS8–13 F127 2.65x64 TM2 hydrophobic
NTS8–13 F127 2.65x64 TM2 Van der Waals
NTS8–13 H131 ECL1 Van der Waals
NTS8–13 H131 ECL1 polar (hydrogen bond with backbone)
NTS8–13 H132 ECL1 polar (hydrogen bond with backbone)
NTS8–13 H132 ECL1 Van der Waals
NTS8–13 Y145 3.29x29 TM3 Van der Waals
NTS8–13 Y145 3.29x29 TM3 polar (hydrogen bond)
NTS8–13 V223 ECL2 Van der Waals
NTS8–13 T225 45.51x51 ECL2 Van der Waals
NTS8–13 R322 6.54x54 TM6 polar (charge-assisted hydrogen bond)
NTS8–13 R323 6.55x55 TM6 Van der Waals
NTS8–13 F326 6.58x58 TM6 polar (hydrogen bond with backbone)
NTS8–13 F326 6.58x58 TM6 Van der Waals
NTS8–13 I329 6.61x61 TM6 polar (hydrogen bond with backbone)
NTS8–13 I329 6.61x61 TM6 Van der Waals
NTS8–13 S330 ECL3 Van der Waals
NTS8–13 W334 ECL3 polar (hydrogen bond)
NTS8–13 W334 ECL3 polar (hydrogen bond with backbone)
NTS8–13 Y339 7.28x27 TM7 Van der Waals
NTS8–13 Y339 7.28x27 TM7 hydrophobic
NTS8–13 Y342 7.31x30 TM7 polar (hydrogen bond)
NTS8–13 Y342 7.31x30 TM7 Van der Waals
NTS8–13 Y346 7.35x34 TM7 hydrophobic
NTS8–13 Y346 7.35x34 TM7 Van der Waals

Ligands

NTS8–13

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Residue Diagrams

T N G V T G V V F L A L Y V A T V L V K 1 G S L A L S D L L T L L L A M P V E L Y N 2 S A V N L A T A Y T C A D R L F Y Y G R 3 T K K F I S A I W L A S A L L A V P M 4 N L V S I V V M P F I F S M F T N V Q I V 5 R A V V I A F V V C W L P Y H V R R L M 6 I P N I T S S V Y F L A N T V M Y F Y 7
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ICL1 K S L Q ICL1ECL1 H H P W A F ECL1ICL2 P F K A K T L M ICL2ECL2 G E Q N R S A D G Q H A G G L V C T P T I ECL2ICL3 Q V C T V G G E H S T F S M A I E ICL3ECL3 S D E Q W ECL3N-term M R L N S S A P G T P G T P A A D P F Q R A Q A G L E E A L L A P G F G N A S G N A S E R V L A A P S S E L D V N T N-termC-term P V W R R R R K R P A F S R K A D S V S S N H T L S S N A T R E T L Y C-term D I Y S K V L V T A V Y L A L F V V G T V G N T V T A F T L A R K S L Q S T V H Y H L G S L A L S D L L T L L L A M P V E L Y N F I W V G D A G C R G Y Y F L R D A C T Y A T A L N V A S L S V E R Y L A I C H S R S R T K K F I S A I W L A S A L L A V P M L F T M H T A T V K V V I Q V N T F M S F I F P M V V I S V L N T I I A N K L T V M V R Q A A E Q G P G R V Q A L R H G V R V L R A V V I A F V V C W L P Y H V R R L M F C Y I T P F L Y D F Y H Y F Y M V T N A L F Y V S S T I N P I L Y N L V S A N F L A L C F R H I T L A C
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Residue Table


GPCRdb(A)
GPCRdb(A)
NTS1 receptor
TM2
2x64 2.65x64 F127
TM3
3x29 3.29x29 Y145
ECL2
45x51 45.51x51 T225
TM6
6x54 6.54x54 R322
6x55 6.55x55 R323
6x58 6.58x58 F326
6x61 6.61x61 I329
TM7
7x27 7.28x27 Y339
7x30 7.31x30 Y342
7x34 7.35x34 Y346