Structure information

5-HT1A receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

9R41

SPECIES

Homo sapiens

RESOLUTION

3.800

PREFERRED CHAIN

R

REFERENCE

PUBLICATION DATE

May 20, 2026

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
buspirone D116 3.32x32 TM3 polar (charge-assisted hydrogen bond)
buspirone V117 3.33x33 TM3 hydrophobic
buspirone V117 3.33x33 TM3 Van der Waals
buspirone C120 3.36x36 TM3 Van der Waals
buspirone T188 45.51x51 ECL2 Van der Waals
buspirone I189 45.52x52 ECL2 Van der Waals
buspirone I189 45.52x52 ECL2 hydrophobic
buspirone S199 5.42x43 TM5 Van der Waals
buspirone F361 6.51x51 TM6 Van der Waals
buspirone F361 6.51x51 TM6 hydrophobic
buspirone F362 6.52x52 TM6 Van der Waals
buspirone N386 7.39x38 TM7 Van der Waals
buspirone Y390 7.43x42 TM7 Van der Waals
buspirone Y390 7.43x42 TM7 hydrophobic

Ligands

buspirone

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Residue Diagrams

A N G L V A C F I L T G L L L S T I V Q 1 G S L A V T D L M V S L V V L P M A A L Y 2 A C L H L I S S T C C L V D L A I F L D 3 A A A L I S L T W L I G F L I S I P P M 4 Y L V L M L L L P I Y F A G F T S Y I T Y 5 G I I M G T F I L C W L P F F I V A L V 6 V P N L L S N S Y G L W N I I A G L L 7
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ICL1 R S L Q ICL1ECL1 K W T L ECL1ICL2 P I D Y V N K R ICL2ECL2 R T P E D R S D P D A C T I S K ECL2ICL3 E K T G A D T R H G A S P A P Q P K K S V N G E S G S R N W R L G V E S K A G G A L C A N G A V R Q G D D G A A L E V I E V H R V G N S K E H L P L P S E A G P T P C A P A S F E R ICL3ECL3 E S S C H M ECL3N-term M D V L S P G Q G N N T T S P P A P F E T G G N T T G I S D V N-termC-term K C K F C R Q C-term T V S Y Q V I T S L L L G T L I F C A V L G N A C V V A A I A L E N V A N Y L I G S L A V T D L M V S V L V L P M A A L Y Q V L N G Q V T C D L F I A L D V L C C T S S I L H L C A I A L D R Y W A I T D T P R R A A A L I S L T W L I G F L I S I P P M L G W D H G Y T I Y S T F G A F Y I P L L L M L V L Y G R I F R A A R F R I R K T V K K V K N E R N A E A K R K M A L A R E R K T V K T L G I I M G T F I L C W L P F F I V A L V L P F C P T L L G A I I N W L G Y S N S L L N P V I Y A Y F N K D F K K F Q N A I I
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Residue Table


GPCRdb(A)
GPCRdb(A)
5-HT1A receptor
TM3
3x32 3.32x32 D116
3x33 3.33x33 V117
3x36 3.36x36 C120
ECL2
45x51 45.51x51 T188
45x52 45.52x52 I189
TM5
5x43 5.42x43 S199
TM6
6x51 6.51x51 F361
6x52 6.52x52 F362
TM7
7x38 7.39x38 N386
7x42 7.43x42 Y390