Structure information

NPFF1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

9VIF

SPECIES

Homo sapiens

RESOLUTION

3.190

PREFERRED CHAIN

A

REFERENCE

10.1093/PROCEL/PWAF090

PUBLICATION DATE

Dec. 3, 2025

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
neuropeptide FF (Human) V127 3.36x36 TM3 hydrophobic
neuropeptide FF (Human) S176 4.60x61 TM4 polar (hydrogen bond)
neuropeptide FF (Human) S176 4.60x61 TM4 Van der Waals
neuropeptide FF (Human) E205 45.52x52 ECL2 polar (charge-assisted hydrogen bond)
neuropeptide FF (Human) W287 6.52x52 TM6 Van der Waals
neuropeptide FF (Human) W287 6.52x52 TM6 aromatic (face-to-edge)
neuropeptide FF (Human) L290 6.55x55 TM6 Van der Waals
neuropeptide FF (Human) I293 6.58x58 TM6 Van der Waals
neuropeptide FF (Human) T307 7.31x30 TM7 Van der Waals
neuropeptide FF (Human) H315 7.39x38 TM7 polar (hydrogen bond)

Ligands

neuropeptide FF (Human)

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Residue Diagrams

T N G V M C L L F I L A Y A V I F M A A 1 L N L A V S D L L V G F I C M P T T L V D 2 A V L T F V S A S V S M G Q V L G S M K 3 A L V T I A V I W A L A L L I M C P S 4 Y M V V I L A L P A L Y I H S F L V T T Y 5 V M V A L F F T L S W L P L W A L L L L 6 I P N A S S N F F A L W H A F P F A Y 7
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ICL1 R H M H ICL1ECL1 G W P F ECL1ICL2 P F R E K L ICL2ECL2 T V T R E E H H F M V D A R N R S Y P L Y S C W E A W P E K ECL2ICL3 G G E E A ICL3ECL3 Q L S A P Q L ECL3N-term M E G E P S Q P P N S S W P L S Q N G T N T E A T P A T N L T F S S Y Y Q H T S P V N-termC-term P R P S G S H K E A Y S E R P G G L L H R R V F V V V R P S D S G L P S E S G P S S G A P R P G R L P L R N G R V A H H G L P R E G P G C S H L P L T I P A W D I C-term A A M F I V A Y A L I F L L C M V G N T L V C F I V L K N T V T N M F I L N L A V S D L L V G I F C M P T T L V D N L I T D N A T C K M S G L V Q G M S V S A S V F T L V A I A V E R F R C I V H T L R K A L V T I A V I W A L A L L I M C P S A V T L G M R R V Y T T V L F S H I Y L A P L A L I V V M Y A R I A R K L C Q A P G P A P A D P R A S R R R A R V V H M L V M V A L F F T L S W L P L W A L L L L I D Y G H L V T V Y A F P F A H W L A F F N S S A N P I I Y G Y F N E N F Q A R L C F R R G A F R A
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Residue Table


GPCRdb(A)
GPCRdb(A)
NPFF1 receptor
TM3
3x36 3.36x36 V127
TM4
4x61 4.60x61 S176
ECL2
45x52 45.52x52 E205
TM6
6x52 6.52x52 W287
6x55 6.55x55 L290
6x58 6.58x58 I293
TM7
7x30 7.31x30 T307
7x38 7.39x38 H315