Structure information

S1P1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

9VO1

SPECIES

Homo sapiens

RESOLUTION

2.970

PREFERRED CHAIN

F

REFERENCE

PUBLICATION DATE

Jan. 28, 2026

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
SAR247799 T109 23.50x50 ECL1 polar (hydrogen bond)
SAR247799 T109 23.50x50 ECL1 Van der Waals
SAR247799 R120 3.28x28 TM3 polar (charge-assisted hydrogen bond)
SAR247799 F125 3.33x33 TM3 aromatic (face-to-face)
SAR247799 F125 3.33x33 TM3 Van der Waals
SAR247799 L128 3.36x36 TM3 Van der Waals
SAR247799 L128 3.36x36 TM3 hydrophobic
SAR247799 S129 3.37x37 TM3 Van der Waals
SAR247799 L195 ECL2 Van der Waals
SAR247799 L195 ECL2 hydrophobic
SAR247799 C206 5.43x43 TM5 Van der Waals
SAR247799 L272 6.51x51 TM6 hydrophobic
SAR247799 L272 6.51x51 TM6 Van der Waals
SAR247799 L276 6.55x55 TM6 hydrophobic
SAR247799 L276 6.55x55 TM6 Van der Waals
SAR247799 L297 7.39x38 TM7 hydrophobic

Ligands

SAR247799

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Residue Diagrams

I N E L I I F C C I L I F V V S T L K I 1 G N L A L S D L L A G V A Y T A N L L L 2 A L L S F V S A S L A V F M S G E R L F 3 L F L L I S A C W V I S L I L G G L P I 4 Y L I V I S L L L L T F V T T C F L I Y 5 I I V L S V F I A C W A P L F I L L L L 6 I P N T G S N L V A L V L F Y E A R F 7
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ICL1 K K F H ICL1ECL1 G A T T Y K L ECL1ICL2 M K L H N G S ICL2ECL2 W N C I S A L S S C S T V L P L Y ECL2ICL3 F R K N I S K A ICL3ECL3 K V K T C ECL3N-term M G P T S V P L V K A H R S S V S D Y V N Y D I I V R H Y N Y T G K L N I S A D K N-termC-term C C K C P S G D S A G K F K R P I I A G M E F S R S K S D N S S H P Q K D E G D N P E T I M S S G N V N S S S C-term E N S I K L T S V V F I L I C C F I I L E N I F V L L T I W K T R P M Y Y F I G N L A L S D L L A G V A Y T A N L L L S T P A Q W F L R E G S M F V A L S A S V F S L L A I A I E R Y I T M L K N N F R L F L L I S A C W V I S L I L G G L P I M G H K H Y I L F C T T V F T L L L L S I V I L Y C R I Y S L V R T R S R R L T S R S S E K S L A L L K T V I I V L S V F I A C W A P L F I L L L L D V G C D I L F R A E Y F L V L A V L N S G T N P I I Y T L T N K E F I R M R R A I M S
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Residue Table


GPCRdb(A)
GPCRdb(A)
S1P1 receptor
ECL1
23x50 23.50x50 T109
TM3
3x28 3.28x28 R120
3x33 3.33x33 F125
3x36 3.36x36 L128
3x37 3.37x37 S129
TM5
5x43 5.43x43 C206
TM6
6x51 6.51x51 L272
6x55 6.55x55 L276
TM7
7x38 7.39x38 L297