Structure information

TAS2R46

PROTEIN CLASS

Class T2 (Taste 2)

PDB CODE

9W0S

SPECIES

Homo sapiens

RESOLUTION

3.300

PREFERRED CHAIN

R

REFERENCE

PUBLICATION DATE

April 22, 2026

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Artemisinin N65 2.60x60 TM2 polar (hydrogen bond)
Artemisinin N65 2.60x60 TM2 Van der Waals
Artemisinin Y85 3.29x29 TM3 Van der Waals
Artemisinin Y85 3.29x29 TM3 hydrophobic
Artemisinin W88 3.32x32 TM3 polar (hydrogen bond)
Artemisinin W88 3.32x32 TM3 Van der Waals
Artemisinin S248 6.55x55 TM6 Van der Waals
Artemisinin V249 6.56x56 TM6 Van der Waals
Artemisinin F252 6.59x59 TM6 Van der Waals
Artemisinin F252 6.59x59 TM6 hydrophobic
Artemisinin E265 7.39x38 TM7 polar (charge-assisted hydrogen bond)

Ligands

Artemisinin

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Residue Diagrams

G N A F N G I V F T V V I L I S F I I P 1 T A L A V S R V G L L W V L V L N W Y A 2 S T A L W N S F H N I V A W V N Y A T I 3 V L V I L L G P L L F L V C H L F V I N 4 F S I L T L T F P V L N A L I T V T T N 5 V T S F L L L C A I Y F L S I I M S V W 6 F P H T S P Y S F A I A E C F M F V P 7
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ICL1 K I ICL1ECL1 P A F N ECL1ICL2 N F S N L I F L H L K R ICL2ECL2 I W T K E Y E G N M T W K I K L R S A M Y L S ECL2ICL3 K G S Q ICL3ECL3 L E N ECL3N-term M N-termC-term K G E K P S S S C-term I T F L P I I F S I L I V V T F V I G N F A N G F I A L V N S I E W F K R Q S F A D Q I L T A L A V S R V G L L W V L V L N W Y A T E L N S I E V R I T A Y N V W A V I N H F S N W L A T S L S I F Y L L K I A R V K S V V L V I L L G P L L F L V C H L F V I N M N Q I N T T V T I L A N L V P F T L T L I S F L L L I C S L C K H L K K M Q L H G D P S M K V H I K A L Q T V T S F L L L C A I Y F L S I I M S V W S F E S K P V F M F C E A I A F S Y P S T H P F I L I W G N K K F L S V R Y L K Q T V L W H W V
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Residue Table


GPCRdb(A)
GPCRdb(A)
TAS2R46
TM2
2x60 2.60x60 N65
TM3
3x29 3.29x29 Y85
3x32 3.32x32 W88
TM6
6x55 6.55x55 S248
6x56 6.56x56 V249
6x59 6.59x59 F252
TM7
7x38 7.39x38 E265