Structure information

TAS2R46

PROTEIN CLASS

Class T2 (Taste 2)

PDB CODE

9W0U

SPECIES

Homo sapiens

RESOLUTION

2.900

PREFERRED CHAIN

R

REFERENCE

PUBLICATION DATE

April 22, 2026

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
TANGERETIN L62 2.57x57 TM2 hydrophobic
TANGERETIN N65 2.60x60 TM2 polar (hydrogen bond)
TANGERETIN N65 2.60x60 TM2 Van der Waals
TANGERETIN Y85 3.29x29 TM3 hydrophobic
TANGERETIN W88 3.32x32 TM3 Van der Waals
TANGERETIN W88 3.32x32 TM3 aromatic (face-to-face)
TANGERETIN L168 ECL2 hydrophobic
TANGERETIN L168 ECL2 Van der Waals
TANGERETIN R169 ECL2 Van der Waals
TANGERETIN M172 ECL2 Van der Waals
TANGERETIN N176 5.39x40 TM5 Van der Waals
TANGERETIN F269 7.43x42 TM7 Van der Waals

Ligands

TANGERETIN

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Residue Diagrams

G N A F N G I V F T V V I L I S F I I P 1 T A L A V S R V G L L W V L V L N W Y A 2 S T A L W N S F H N I V A W V N Y A T I 3 V L V I L L G P L L F L V C H L F V I N 4 F S I L T L T F P V L N A L I T V T T N 5 V T S F L L L C A I Y F L S I I M S V W 6 F P H T S P Y S F A I A E C F M F V P 7
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ICL1 K I ICL1ECL1 P A F N ECL1ICL2 N F S N L I F L H L K R ICL2ECL2 I W T K E Y E G N M T W K I K L R S A M Y L S ECL2ICL3 K G S Q ICL3ECL3 L E N ECL3N-term M N-termC-term K G E K P S S S C-term I T F L P I I F S I L I V V T F V I G N F A N G F I A L V N S I E W F K R Q S F A D Q I L T A L A V S R V G L L W V L V L N W Y A T E L N S I E V R I T A Y N V W A V I N H F S N W L A T S L S I F Y L L K I A R V K S V V L V I L L G P L L F L V C H L F V I N M N Q I N T T V T I L A N L V P F T L T L I S F L L L I C S L C K H L K K M Q L H G D P S M K V H I K A L Q T V T S F L L L C A I Y F L S I I M S V W S F E S K P V F M F C E A I A F S Y P S T H P F I L I W G N K K F L S V R Y L K Q T V L W H W V
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Residue Table


GPCRdb(A)
GPCRdb(A)
TAS2R46
TM2
2x57 2.57x57 L62
2x60 2.60x60 N65
TM3
3x29 3.29x29 Y85
3x32 3.32x32 W88
TM5
5x40 5.39x40 N176
TM7
7x42 7.43x42 F269