Structure information

CCR7

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

9XHI

SPECIES

Homo sapiens

RESOLUTION

3.200

PREFERRED CHAIN

R

REFERENCE

10.1073/PNAS.2533975123

PUBLICATION DATE

April 22, 2026

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
C-C motif chemokine 21 V39 N-term hydrophobic
C-C motif chemokine 21 Y41 N-term aromatic (face-to-face)
C-C motif chemokine 21 L43 N-term hydrophobic
C-C motif chemokine 21 F44 N-term hydrophobic
C-C motif chemokine 21 E45 N-term polar (hydrogen bond with backbone)
C-C motif chemokine 21 E45 N-term Van der Waals
C-C motif chemokine 21 S46 N-term polar (hydrogen bond)
C-C motif chemokine 21 S46 N-term Van der Waals
C-C motif chemokine 21 L47 N-term Van der Waals
C-C motif chemokine 21 L47 N-term polar (hydrogen bond with backbone)
C-C motif chemokine 21 C48 N-term Van der Waals
C-C motif chemokine 21 S49 N-term Van der Waals
C-C motif chemokine 21 K50 N-term Van der Waals
C-C motif chemokine 21 K50 N-term polar (hydrogen bond with backbone)
C-C motif chemokine 21 V53 N-term Van der Waals
C-C motif chemokine 21 V53 N-term hydrophobic
C-C motif chemokine 21 R54 N-term polar (charge-assisted hydrogen bond)
C-C motif chemokine 21 K57 1.31x31 TM1 Van der Waals
C-C motif chemokine 21 Q200 ECL2 polar (hydrogen bond)
C-C motif chemokine 21 Q200 ECL2 polar (hydrogen bond)
C-C motif chemokine 21 Q200 ECL2 polar (hydrogen bond)
C-C motif chemokine 21 R209 ECL2 polar (charge-assisted hydrogen bond)
C-C motif chemokine 21 L212 45.52x52 ECL2 polar (hydrogen bond with backbone)
C-C motif chemokine 21 L212 45.52x52 ECL2 Van der Waals
C-C motif chemokine 21 I213 ECL2 Van der Waals
C-C motif chemokine 21 I213 ECL2 hydrophobic
C-C motif chemokine 21 T214 ECL2 Van der Waals
C-C motif chemokine 21 T214 ECL2 polar (hydrogen bond with backbone)
C-C motif chemokine 21 V217 5.32x33 TM5 Van der Waals
C-C motif chemokine 21 F220 5.35x36 TM5 Van der Waals
C-C motif chemokine 21 F220 5.35x36 TM5 hydrophobic
C-C motif chemokine 21 Q286 6.58x58 TM6 polar (hydrogen bond)
C-C motif chemokine 21 N290 6.62x62 TM6 polar (hydrogen bond)
C-C motif chemokine 21 N290 6.62x62 TM6 polar (hydrogen bond)
C-C motif chemokine 21 S295 ECL3 Van der Waals
C-C motif chemokine 21 S296 ECL3 Van der Waals
C-C motif chemokine 21 C298 7.25x24 TM7 Van der Waals
C-C motif chemokine 21 N305 7.32x31 TM7 polar (hydrogen bond)
C-C motif chemokine 21 N305 7.32x31 TM7 Van der Waals
C-C motif chemokine 21 Y308 7.35x34 TM7 polar (hydrogen bond)
C-C motif chemokine 21 Y308 7.35x34 TM7 Van der Waals

Ligands

C-C motif chemokine 21

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Residue Diagrams

G N G L L G V F C I I S Y M I P L F W A 1 L N L A V A D I L F L L T L P F W A Y S 2 C L L L L M G S F F S M K Y I A F I L K 3 S K L S C V G I W I L A T V L S I P E 4 Y C F S M A L L P V L F G I V M Q A V Q I 5 I A V V V V F I V F Q L P Y N G V V L A 6 F P N V C C R V C A L S Y T V D Y A I 7
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ICL1 K R L K ICL1ECL1 S W V F ECL1ICL2 A V S A H R H R A R ICL2ECL2 D L Q R S S S E Q A M R C S L I T E H V ECL2ICL3 R N ICL3ECL3 T S S ECL3N-term M D L G K P M K S V L V V A L L V I F Q V C L C Q D E V T D D Y I G D N T T V D Y T L F E S L C S K K D V R N-termC-term D L G C L S Q E Q L R Q W S S C R H I R R S S M S V E A E T T T T F S P C-term N F K A W F L P I M Y S I I C F V G L L G N G L V V L T Y I Y F T M T D T Y L L N L A V A D I L F L L T L P F W A Y S A A K G V H F C K L I F A I Y K M S F F S G M L L L L C I S I D R Y V A I V Q V L L I S K L S C V G I W I L A T V L S I P E L L Y S E A F I T I Q V A Q M V I G F L V P L L A M S F C Y L V I I R T L L Q A F E R N K A I K V I I A V V V V F I V F Q L P Y N G V V L A Q T V A N F N I T C E L S K Q L N I A Y D V T Y S L A C V R C C V N P F L Y A F I G V K L F K F R N D L F K
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Residue Table


GPCRdb(A)
GPCRdb(A)
CCR7
TM1
1x31 1.31x31 K57
ECL2
45x52 45.52x52 L212
TM5
5x36 5.35x36 F220
TM6
6x58 6.58x58 Q286
6x62 6.62x62 N290
TM7
7x24 7.25x24 C298
7x31 7.32x31 N305
7x34 7.35x34 Y308