CHEMBL3084503


SMILES O[C@]1(c2ccc(Cl)c(Cl)c2)C[C@@H]2CC[C@H](C1)N2Cc1c[nH]c2ccccc12
InChIKey GZFSOKPLNMYPCE-YPGOJHLTSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 3
Molecular weight (Da) 400.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D4 DRD4 Human Dopamine A pKi 6.44 6.44 6.44 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 5.62 5.62 5.62 ChEMBL
D3 DRD3 Human Dopamine A pKi 8.2 8.2 8.2 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 5.55 5.55 5.55 ChEMBL
D2 DRD2 Human Dopamine A pKi 7.45 7.45 7.45 ChEMBL
D1 DRD1 Human Dopamine A pKi 5.77 5.77 5.77 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D3 DRD3 Human Dopamine A pIC50 7.99 7.99 7.99 ChEMBL
D2 DRD2 Human Dopamine A pIC50 6.68 6.68 6.68 ChEMBL