CP-481,715


SMILES O[C@H]([C@@H](NC(=O)c1cnc2c(n1)cccc2)Cc1cccc(c1)F)C[C@H](C(=O)N)CCC(O)(C)C
InChIKey YEQJVHQCUDMXFG-FHZYATBESA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 4
Rotatable bonds 11
Molecular weight (Da) 482.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
CCR1 CCR1 Human Chemokine A pKd 8.0 8.0 8.0 Guide to Pharmacology
CCR1 CCR1 Human Chemokine A pKi 7.13 7.13 7.13 ChEMBL
CCR5 CCR5 Human Chemokine A pKi 7.18 7.18 7.18 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 5.88 5.88 5.88 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
CCR1 CCR1 Human Chemokine A pIC50 7.23 7.32 7.41 ChEMBL