CHEMBL3597592


SMILES O=[N+]([O-])c1cccnc1N1CCC(=CC#Cc2ccccc2)CC1
InChIKey YATZGLPZEVHKJR-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 2
Molecular weight (Da) 319.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu1 GRM1 Rat Metabotropic glutamate C pKi 8.32 8.32 8.32 ChEMBL
mGlu5 GRM5 Rat Metabotropic glutamate C pKi 9.22 9.22 9.22 ChEMBL
mGlu5 GRM5 Human Metabotropic glutamate C pKi 9.4 9.4 9.4 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu1 GRM1 Rat Metabotropic glutamate C pIC50 7.41 7.41 7.41 ChEMBL
mGlu5 GRM5 Human Metabotropic glutamate C pIC50 8.55 8.55 8.55 ChEMBL