CHEMBL3669443


SMILES Cc1cc2c(CN3CCCC4(CCN(c5cnc6ccccc6n5)CC4)C3=O)cccc2[nH]1
InChIKey SKLKXAKXZQKETK-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 3
Molecular weight (Da) 439.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
OX1 OX1R Human Orexin A pKi 6.44 6.44 6.44 ChEMBL
OX1 OX1R Human Orexin A pKd 6.11 6.11 6.11 ChEMBL
OX2 OX2R Human Orexin A pKd 7.21 7.21 7.21 ChEMBL
OX2 OX2R Human Orexin A pKi 7.46 7.46 7.46 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database