danuglipron


SMILES Fc1cc(C#N)ccc1COc1cccc(C2CCN(Cc3nc4ccc(C(=O)O)cc4n3C[C@@H]3CCO3)CC2)n1
InChIKey HYBAKUMPISVZQP-DEOSSOPVSA-N

Chemical properties

Hydrogen bond acceptors 8
Hydrogen bond donors 1
Rotatable bonds 9
Molecular weight (Da) 555.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Structure pdb 7LCI 6X1A 7LCJ 7LCK

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
GLP-1 GLP1R Human Glucagon B1 pKi 6.44 6.44 6.44 Guide to Pharmacology
GLP-1 GLP1R Human Glucagon B1 pKi 6.44 6.77 7.1 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
GLP-1 GLP1R Human Glucagon B1 pEC50 6.12 7.57 9.15 ChEMBL