CHEMBL371730


SMILES O=C(CCN1CCC(Cc2c[nH]cn2)CC1)Nc1ccc(Cl)cc1
InChIKey PXZWAKNYGHYHEV-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 6
Molecular weight (Da) 346.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H3 HRH3 Guinea pig Histamine A pKi 9.4 9.4 9.4 ChEMBL
H3 HRH3 Guinea pig Histamine A pKd 10.1 10.1 10.1 ChEMBL
H1 HRH1 Guinea pig Histamine A pKi 6.54 6.54 6.54 ChEMBL
H3 HRH3 Human Histamine A pKi 8.77 8.77 8.77 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database