CHEMBL390718


SMILES COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C(C)=C/c4ccccc4)CC3)C1CN2
InChIKey JODRRUQCPGURFJ-CPNJWEJPSA-N

Chemical properties

Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 7
Molecular weight (Da) 462.3

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α2B ADA2B Human Adrenoceptors A pKi 7.58 7.95 8.35 ChEMBL
α2C ADA2C Human Adrenoceptors A pKi 8.08 9.04 10.0 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 7.06 8.19 8.89 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database