evocalcet


SMILES OC(=O)Cc1ccc(cc1)N1CC[C@@H](C1)N[C@@H](c1cccc2c1cccc2)C
InChIKey RZNUIYPHQFXBAN-XLIONFOSSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 6
Molecular weight (Da) 374.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Structure pdb 7M3G 7DD7

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
CaS CASR Human Calcium-sensing C pEC50 7.03 7.03 7.03 Guide to Pharmacology
CaS CASR Rat Calcium-sensing C pIC50 7.51 7.51 7.51 ChEMBL
CaS CASR Human Calcium-sensing C pEC50 7.03 7.03 7.03 ChEMBL
CaS CASR Human Calcium-sensing C pEC50 8.15 8.15 8.15 Drug Central