6-hydroxymelatonin


SMILES COc1cc2c(CCNC(=O)C)c[nH]c2cc1O
InChIKey OMYMRCXOJJZYKE-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 3
Rotatable bonds 4
Molecular weight (Da) 248.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
MT1 MTR1A Human Melatonin A pKi 8.9 9.05 9.2 Guide to Pharmacology
MT2 MTR1B Human Melatonin A pKi 8.3 8.55 8.8 Guide to Pharmacology
MT2 MTR1B Human Melatonin A pKi 8.26 8.26 8.26 ChEMBL
MT1 MTR1A Human Melatonin A pKi 7.4 7.4 7.4 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
NPS NPSR1 Human Neuropeptide S A Potency 5.0 5.0 5.0 ChEMBL