CHEMBL4448320


SMILES Cc1cccc(NC(=O)CN2CCN(c3ccccn3)CC2)c1
InChIKey AJADIMFRRRXJAI-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 4
Molecular weight (Da) 310.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D4 DRD4 Human Dopamine A pKi 6.67 7.7 8.72 ChEMBL
D3 DRD3 Human Dopamine A pKi 5.19 5.19 5.19 ChEMBL
D2 DRD2 Human Dopamine A pKi 5.48 5.48 5.48 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D4 DRD4 Human Dopamine A pEC50 6.41 7.42 8.44 ChEMBL
D4 DRD4 Human Dopamine A pIC50 6.5 6.79 7.08 ChEMBL
D3 DRD3 Human Dopamine A pEC50 5.2 5.2 5.2 ChEMBL
D2 DRD2 Human Dopamine A pEC50 4.58 5.35 6.12 ChEMBL
D2 DRD2 Human Dopamine A pIC50 4.8 4.8 4.8 ChEMBL