CHEMBL460636


SMILES CN(C)CCN1CN(c2ccccc2)C2(CCN(C(c3ccccc3Cl)c3ccccc3Cl)CC2)C1=O
InChIKey KTAGYIIOIMNXTN-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 7
Molecular weight (Da) 536.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
NOP OPRX Human Opioid A pKi 8.46 8.46 8.46 ChEMBL
μ OPRM Human Opioid A pKi 6.38 6.38 6.38 ChEMBL
δ OPRD Human Opioid A pKi 6.03 6.03 6.03 PDSP Ki database
NOP OPRX Human Opioid A pKi 8.46 8.46 8.46 PDSP Ki database
κ OPRK Human Opioid A pKi 6.49 6.49 6.49 PDSP Ki database
μ OPRM Human Opioid A pKi 6.38 6.38 6.38 PDSP Ki database
δ OPRD Human Opioid A pKi 6.03 6.03 6.03 ChEMBL
κ OPRK Human Opioid A pKi 6.5 6.5 6.5 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database