MUSCARINE


SMILES C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O
InChIKey UQOFGTXDASPNLL-XHNCKOQMSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 2
Molecular weight (Da) 174.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M4 ACM4 Rat Acetylcholine (muscarinic) A pKi 5.85 5.85 5.85 ChEMBL
M3 ACM3 Rat Acetylcholine (muscarinic) A pKi 4.67 4.67 4.67 ChEMBL
M2 ACM2 Rat Acetylcholine (muscarinic) A pKi 6.31 6.71 7.12 ChEMBL
M1 ACM1 Rat Acetylcholine (muscarinic) A pKi 4.82 6.63 7.92 ChEMBL
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 4.55 6.01 7.64 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 6.31 7.04 7.6 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 4.74 6.0 7.25 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M4 ACM4 Rat Acetylcholine (muscarinic) A pIC50 6.33 6.33 6.33 ChEMBL
M3 ACM3 Rat Acetylcholine (muscarinic) A pEC50 6.89 6.89 6.89 ChEMBL
M2 ACM2 Rat Acetylcholine (muscarinic) A pIC50 5.41 5.86 6.31 ChEMBL
M1 ACM1 Rat Acetylcholine (muscarinic) A pIC50 5.25 5.25 5.25 ChEMBL
M1 ACM1 Rat Acetylcholine (muscarinic) A pEC50 6.66 6.66 6.66 ChEMBL
M1 ACM1 Rat Acetylcholine (muscarinic) A Potency 5.6 5.6 5.6 ChEMBL
M5 ACM5 Human Acetylcholine (muscarinic) A pEC50 5.89 5.89 5.89 ChEMBL
M3 ACM3 Human Acetylcholine (muscarinic) A pEC50 6.0 6.0 6.0 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pIC50 5.41 5.88 6.35 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pEC50 5.28 5.28 5.28 ChEMBL
TSH TSHR Human Glycoprotein hormone A Potency 5.1 5.1 5.1 ChEMBL