CHEMBL4794963


SMILES CC(=O)Nc1ccc(OCCCCN2CCC(c3noc4cc(F)ccc34)CC2)cc1
InChIKey TZFKQPVOFBQHAZ-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 8
Molecular weight (Da) 425.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H1 HRH1 Human Histamine A pKi 7.27 7.27 7.27 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 6.71 6.71 6.71 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 6.12 6.12 6.12 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 6.73 6.73 6.73 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 6.65 6.65 6.65 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 5.91 5.91 5.91 ChEMBL
D2 DRD2 Human Dopamine A pKi 5.94 5.94 5.94 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database