OLICERIDINE


SMILES COc1ccsc1CNCC[C@@]1(c2ccccn2)CCOC2(CCCC2)C1
InChIKey DMNOVGJWPASQDL-OAQYLSRUSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 7
Molecular weight (Da) 386.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Structure pdb 8EFB

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
μ OPRM Human Opioid A pKi 8.09 8.09 8.09 Drug Central
μ OPRM Human Opioid A pKi 7.57 8.25 8.84 ChEMBL
D2 DRD2 Human Dopamine A pKi 4.08 4.08 4.08 ChEMBL
D3 DRD3 Human Dopamine A pKi 5.16 5.16 5.16 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
μ OPRM Mouse Opioid A pEC50 7.23 7.78 8.62 ChEMBL
δ OPRD Human Opioid A pEC50 5.55 5.55 5.55 ChEMBL
κ OPRK Human Opioid A pEC50 5.85 5.85 5.85 ChEMBL
NOP OPRX Human Opioid A pEC50 8.13 8.13 8.13 Drug Central
μ OPRM Human Opioid A pEC50 7.3 8.12 8.74 ChEMBL