CHEMBL494890


SMILES N#Cc1ccc(-c2cc(N3CCNCC3)nc(N)n2)cc1
InChIKey GXPQVRIHPFBPOG-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 2
Molecular weight (Da) 280.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H4 HRH4 Rat Histamine A pKi 6.47 6.47 6.47 ChEMBL
H3 HRH3 Rat Histamine A pKi 6.92 6.92 6.92 ChEMBL
H4 HRH4 Human Histamine A pKi 7.38 7.38 7.38 ChEMBL
H3 HRH3 Human Histamine A pKi 6.03 6.03 6.03 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H4 HRH4 Mouse Histamine A pEC50 6.99 6.99 6.99 ChEMBL
H4 HRH4 Rat Histamine A pEC50 6.61 6.61 6.61 ChEMBL