CHEMBL5274312


SMILES CC[Si](C#Cc1cccc2c1OC(C(F)(F)F)C([N+](=O)[O-])=C2)(CC)CC
InChIKey IHIRLDQLFPQTJC-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 4
Molecular weight (Da) 383.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α2B ADA2B Human Adrenoceptors A pKi 5.72 5.72 5.72 ChEMBL
α2C ADA2C Human Adrenoceptors A pKi 5.96 5.96 5.96 ChEMBL
β3 ADRB3 Human Adrenoceptors A pKi 5.14 5.14 5.14 ChEMBL
H1 HRH1 Human Histamine A pKi 5.46 5.46 5.46 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 5.38 5.38 5.38 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
P2Y6 P2RY6 Mouse P2Y A pIC50 5.21 5.21 5.21 ChEMBL
P2Y6 P2RY6 Human P2Y A pIC50 6.34 6.34 6.34 ChEMBL