hydromorphone


SMILES O=C1CC[C@@H]2[C@@]34[C@H]1Oc1c4c(C[C@H]2N(CC3)C)ccc1O
InChIKey WVLOADHCBXTIJK-YNHQPCIGSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 0
Molecular weight (Da) 285.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
δ OPRD Human Opioid A pKi 7.42 7.42 7.42 ChEMBL
κ OPRK Human Opioid A pKi 8.55 8.55 8.55 ChEMBL
μ OPRM Human Opioid A pKi 9.55 9.55 9.55 ChEMBL
δ OPRD Human Opioid A pKi 8.13 8.13 8.13 Drug Central
δ OPRD Human Opioid A pKi 7.42 7.42 7.42 Guide to Pharmacology
κ OPRK Human Opioid A pKi 8.07 8.07 8.07 Drug Central
κ OPRK Human Opioid A pKi 8.55 8.55 8.55 Guide to Pharmacology
μ OPRM Human Opioid A pKi 8.02 8.02 8.02 Drug Central
μ OPRM Human Opioid A pKi 9.55 9.55 9.55 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
κ OPRK Human Opioid A pEC50 7.96 7.96 7.96 ChEMBL
μ OPRM Human Opioid A pEC50 8.59 8.59 8.59 ChEMBL