CHEMBL555146


SMILES C[C@@H]1CCCN1CCc1cc2cc(C(=O)c3ccc(F)cc3)ccc2o1
InChIKey VGSYEFOBFMUWGO-OAHLLOKOSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 5
Molecular weight (Da) 351.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H3 HRH3 Rat Histamine A pKi 9.0 9.0 9.0 ChEMBL
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 5.2 5.2 5.2 ChEMBL
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 6.36 6.36 6.36 ChEMBL
H2 HRH2 Human Histamine A pKi 5.77 5.77 5.77 ChEMBL
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 6.46 6.46 6.46 ChEMBL
H1 HRH1 Human Histamine A pKi 5.26 5.26 5.26 ChEMBL
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 6.69 6.69 6.69 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 5.5 5.5 5.5 ChEMBL
H3 HRH3 Human Histamine A pKi 8.72 9.29 9.57 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 6.33 6.33 6.33 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 5.49 5.49 5.49 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 5.57 5.57 5.57 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 6.37 6.37 6.37 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database