OXYCODONE


SMILES COc1ccc2c3c1O[C@H]1C(=O)CC[C@@]4(O)[C@@H](C2)N(C)CC[C@]314
InChIKey BRUQQQPBMZOVGD-XFKAJCMBSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 1
Molecular weight (Da) 315.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
κ OPRK Rat Opioid A pKi 5.58 5.58 5.58 ChEMBL
κ OPRK Guinea pig Opioid A pKi 6.49 6.49 6.49 ChEMBL
μ OPRM Rat Opioid A pKi 7.36 7.71 8.05 ChEMBL
μ OPRM Human Opioid A pKi 6.88 7.66 7.92 ChEMBL
μ OPRM Human Opioid A pKi 8.11 8.11 8.11 Drug Central
δ OPRD Rat Opioid A pKi 8.22 8.22 8.22 Drug Central
μ OPRM Rat Opioid A pKi 8.13 8.13 8.13 Drug Central
κ OPRK Rat Opioid A pKi 8.25 8.25 8.25 Drug Central
κ OPRK Guinea pig Opioid A pKi 8.19 8.19 8.19 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
κ OPRK Mouse Opioid A pEC50 4.8 4.8 4.8 ChEMBL
μ OPRM Mouse Opioid A pEC50 6.8 6.8 6.8 ChEMBL
μ OPRM Rat Opioid A pEC50 7.6 7.6 7.6 ChEMBL
δ OPRD Human Opioid A pEC50 5.4 5.4 5.4 ChEMBL
κ OPRK Human Opioid A pEC50 4.8 4.8 4.8 ChEMBL
μ OPRM Human Opioid A pEC50 6.3 7.19 7.77 ChEMBL
δ OPRD Human Opioid A pEC50 8.27 8.27 8.27 Drug Central
κ OPRK Human Opioid A pEC50 8.32 8.32 8.32 Drug Central
κ OPRK Mouse Opioid A pEC50 8.32 8.32 8.32 Drug Central
μ OPRM Mouse Opioid A pEC50 8.17 8.17 8.17 Drug Central