ArrestinDb

ipsapirone

SMILES	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1
InChIKey	TZJUVVIWVWFLCD-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors	7
Hydrogen bond donors	0
Rotatable bonds	6
Molecular weight (Da)	401.2

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb
Ligand site mutations	5-HT_1A

Search:

Receptor					Activity				Source
GTP No matches found	Uniprot No matches found	Species No matches found	Family No matches found	Class No matches found	Type No matches found	Min	Avg	Max	Database No matches found
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	8.0	8.27	8.47	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	7.3	8.31	9.62	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKd	8.4	8.4	8.4	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	6.89	8.08	9.64	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	8.6	8.7	8.8	Guide to Pharmacology
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	8.26	8.26	8.26	PDSP Ki database
5-HT_1A	5HT1A	Mouse	5-Hydroxytryptamine	A	pKi	7.92	7.92	7.92	ChEMBL
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	5.0	5.0	5.0	PDSP Ki database
5-HT_1B	F1MGM3	Bovine	5-Hydroxytryptamine	A	pKi	5.0	5.0	5.0	PDSP Ki database
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	5.15	5.15	5.15	PDSP Ki database
5-HT_1D	5HT1D	Rat	5-Hydroxytryptamine	A	pKi	5.82	5.89	5.96	PDSP Ki database
5-HT_1D	F1MMU1	Bovine	5-Hydroxytryptamine	A	pKi	5.0	5.04	5.31	PDSP Ki database
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	4.82	4.82	4.82	ChEMBL
5-HT_2A	5HT2A	Rat	5-Hydroxytryptamine	A	pKi	5.07	5.36	5.78	PDSP Ki database
5-HT_2A	5HT2A	Bovine	5-Hydroxytryptamine	A	pKi	5.2	5.2	5.2	PDSP Ki database
5-HT_2C	K7GSR7	Pig	5-Hydroxytryptamine	A	pKi	5.0	5.1	5.48	PDSP Ki database
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	4.78	4.78	4.78	ChEMBL
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pKi	5.85	5.85	5.85	ChEMBL
D₂	DRD2	Human	Dopamine	A	pKi	5.91	6.26	6.96	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pKi	7.06	7.06	7.06	ChEMBL
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	6.66	6.66	6.66	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	7.34	7.34	7.34	ChEMBL

Showing 1 to 22 of 22 entries

Search:

Receptor					Activity				Source
GTP No matches found	Uniprot No matches found	Species No matches found	Family No matches found	Class No matches found	Type No matches found	Min	Avg	Max	Database No matches found
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pIC50	7.46	7.67	8.09	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pEC50	7.17	7.17	7.17	ChEMBL
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pIC50	4.3	4.39	4.58	ChEMBL
5-HT_2A	5HT2A	Bovine	5-Hydroxytryptamine	A	pIC50	5.12	5.12	5.12	ChEMBL
D₁	DRD1	Bovine	Dopamine	A	pIC50	4.92	4.92	4.92	ChEMBL
D₂	DRD2	Rat	Dopamine	A	pIC50	5.54	5.54	5.54	ChEMBL
D₃	DRD3	Human	Dopamine	A	pIC50	5.92	5.92	5.92	ChEMBL
D₄	DRD4	Human	Dopamine	A	pIC50	5.75	5.75	5.75	ChEMBL
α_1A	ADA1A	Bovine	Adrenoceptors	A	pIC50	5.92	5.92	5.92	ChEMBL
α_2A	ADA2A	Bovine	Adrenoceptors	A	pIC50	5.55	5.55	5.55	ChEMBL

Showing 1 to 10 of 10 entries

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ipsapirone

Chemical properties

Drug properties

Database connections

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