DERMORPHIN


SMILES C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O
InChIKey FHZPGIUBXYVUOY-VWGYHWLBSA-N

Chemical properties

Hydrogen bond acceptors None
Hydrogen bond donors None
Rotatable bonds None
Molecular weight (Da)

Drug properties

Molecular type Protein
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
μ OPRM Mouse Opioid A pKi 8.96 8.96 8.96 ChEMBL
δ OPRD Mouse Opioid A pKi 6.0 6.0 6.0 ChEMBL
μ OPRM Rat Opioid A pKi 8.62 9.25 10.04 ChEMBL
δ OPRD Human Opioid A pKi 6.03 6.03 6.03 ChEMBL
κ OPRK Human Opioid A pKi 5.09 5.09 5.09 ChEMBL
μ OPRM Human Opioid A pKi 7.71 8.59 9.27 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
μ OPRM Mouse Opioid A pIC50 7.78 8.45 9.12 ChEMBL
δ OPRD Mouse Opioid A pIC50 7.13 7.61 7.82 ChEMBL
μ OPRM Rat Opioid A pIC50 8.21 8.65 9.27 ChEMBL
δ OPRD Human Opioid A pIC50 6.53 6.61 6.71 ChEMBL
μ OPRM Human Opioid A pIC50 8.62 8.78 9.14 ChEMBL
μ OPRM Human Opioid A pEC50 6.89 7.32 7.98 ChEMBL