JNJ-40411813


SMILES CCCCn1ccc(c(c1=O)Cl)N1CCC(CC1)c1ccccc1
InChIKey HYOGJHCDLQSAHX-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 5
Molecular weight (Da) 344.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Structure pdb 7E9G 8JD3 8JD5

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu2 GRM2 Human Metabotropic glutamate C pKi 6.75 6.75 6.75 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu2 GRM2 Human Metabotropic glutamate C pIC50 7.17 7.17 7.17 ChEMBL
mGlu2 GRM2 Human Metabotropic glutamate C pEC50 5.59 6.39 7.19 ChEMBL
mGlu2 GRM2 Human Metabotropic glutamate C pEC50 6.83 6.83 6.83 Guide to Pharmacology