JNJ 7777120
| SMILES | CN1CCN(CC1)C(=O)c1cc2c([nH]1)ccc(c2)Cl |
| InChIKey | HUQJRYMLJBBEDO-UHFFFAOYSA-N |
Chemical properties
| Hydrogen bond acceptors | 2 |
| Hydrogen bond donors | 1 |
| Rotatable bonds | 1 |
| Molecular weight (Da) | 277.1 |
Drug properties
| Molecular type | Small molecule |
| Physiological/Surrogate | Surrogate |
| Approved drug | No |
Database connections
| Ligand site mutations | H4 |
Bioactivities
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| H1 | HRH1 | Guinea pig | Histamine | A | pKd | 5.8 | 5.96 | 6.11 | ChEMBL |
| H4 | HRH4 | Human | Histamine | A | pKi | 6.4 | 7.86 | 8.48 | ChEMBL |
| H4 | HRH4 | Human | Histamine | A | pKd | 8.0 | 8.16 | 8.4 | ChEMBL |
| H1 | HRH1 | Human | Histamine | A | pKi | 4.33 | 5.17 | 6.01 | ChEMBL |
| H4 | HRH4 | Rat | Histamine | A | pKi | 8.22 | 8.45 | 8.62 | ChEMBL |
| H3 | HRH3 | Human | Histamine | A | pKi | 4.82 | 5.4 | 5.7 | ChEMBL |
| H4 | HRH4 | Human | Histamine | A | pKd | 8.4 | 8.4 | 8.4 | Guide to Pharmacology |
| H4 | HRH4 | Human | Histamine | A | pKi | 7.8 | 8.05 | 8.3 | Guide to Pharmacology |
| H4 | HRH4 | Mouse | Histamine | A | pKi | 6.9 | 7.75 | 8.41 | ChEMBL |
| H3 | HRH3 | Rat | Histamine | A | pKi | 5.84 | 5.86 | 5.88 | ChEMBL |
| H4 | Q91ZY3 | Guinea pig | Histamine | A | pKi | 5.97 | 5.97 | 5.97 | ChEMBL |
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| H4 | HRH4 | Human | Histamine | A | pIC50 | 6.66 | 7.28 | 8.28 | ChEMBL |
| H4 | HRH4 | Human | Histamine | A | pEC50 | 7.6 | 7.77 | 7.9 | ChEMBL |
| H4 | HRH4 | Rat | Histamine | A | pEC50 | 6.13 | 7.36 | 8.59 | ChEMBL |
| H3 | HRH3 | Human | Histamine | A | pEC50 | 6.0 | 6.0 | 6.0 | ChEMBL |
| H4 | HRH4 | Mouse | Histamine | A | pEC50 | 6.1 | 7.36 | 8.62 | ChEMBL |
| H4 | HRH4 | Mouse | Histamine | A | pIC50 | 7.4 | 7.4 | 7.4 | ChEMBL |