L-733,060


SMILES FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F
InChIKey FCDRFVCGMLUYPG-ROUUACIJSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 4
Molecular weight (Da) 403.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
NK1 NK1R Human Tachykinin A pKi 9.1 9.1 9.1 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
NK1 NK1R Rat Tachykinin A pIC50 9.1 9.1 9.1 ChEMBL
NK1 NK1R Human Tachykinin A pIC50 9.0 9.02 9.06 ChEMBL
TSH TSHR Human Glycoprotein hormone A Potency 4.7 4.7 4.7 ChEMBL
NPS NPSR1 Human Neuropeptide S A Potency 5.0 5.0 5.0 ChEMBL