LY2456302


SMILES Cc1cc(C)cc(c1)[C@@H]1CCCN1Cc1ccc(cc1)Oc1ccc(cc1F)C(=O)N
InChIKey ZHPMYDSXGRRERG-DEOSSOPVSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 6
Molecular weight (Da) 418.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
μ OPRM Human Opioid A pKi 7.64 7.71 7.79 ChEMBL
μ OPRM Human Opioid A pKi 7.62 7.62 7.62 Guide to Pharmacology
δ OPRD Human Opioid A pKi 6.78 6.85 6.91 ChEMBL
δ OPRD Human Opioid A pKi 6.81 6.81 6.81 Guide to Pharmacology
κ OPRK Human Opioid A pKi 9.02 9.11 9.22 ChEMBL
κ OPRK Human Opioid A pKi 9.09 9.09 9.09 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
κ OPRK Human Opioid A pKB 9.09 9.09 9.09 Guide to Pharmacology