CTOP


SMILES NCCC[C@@H]1NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CSSC([C@H](NC(=O)[C@@H](NC1=O)[C@H](O)C)C(=O)N[C@H](C(=O)N)[C@H](O)C)(C)C)NC(=O)[C@@H](Cc1ccccc1)N)Cc1ccc(cc1)O)Cc1c[nH]c2c1cccc2
InChIKey PZWWYAHWHHNCHO-FGHAYEPSSA-N
Sequence FCYWXTXT

Chemical properties

Hydrogen bond acceptors 15
Hydrogen bond donors 14
Rotatable bonds 16
Molecular weight (Da) 1061.4

Drug properties

Molecular type Peptide
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
μ OPRM Human Opioid A pKi 9.7 9.7 9.7 Guide to Pharmacology
δ OPRD Rat Opioid A pKi 6.59 6.59 6.59 ChEMBL
μ OPRM Rat Opioid A pKi 8.89 8.89 8.89 ChEMBL
κ OPRK Guinea pig Opioid A pKi 4.83 4.83 4.83 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
MC1 MSHR Human Melanocortin A pEC50 7.0 7.0 7.0 ChEMBL
δ OPRD Rat Opioid A pIC50 4.87 4.87 4.87 ChEMBL
μ OPRM Rat Opioid A pIC50 8.55 8.55 8.55 ChEMBL
δ OPRD Mouse Opioid A pIC50 4.87 4.87 4.87 ChEMBL