ArrestinDb

mianserin

SMILES	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1
InChIKey	UEQUQVLFIPOEMF-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors	2
Hydrogen bond donors	0
Rotatable bonds	0
Molecular weight (Da)	264.2

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central GPCRdb
Ligand site mutations	5-HT_1A 5-HT_2A 5-HT_2C 5-HT₆

Search:

Receptor					Activity				Source
GTP No matches found	Uniprot No matches found	Species No matches found	Family No matches found	Class No matches found	Type No matches found	Min	Avg	Max	Database No matches found
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKd	6.4	6.4	6.4	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	5.59	6.15	6.4	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	8.21	8.21	8.21	Drug Central
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	6.3	6.3	6.3	ChEMBL
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	8.12	8.12	8.12	Drug Central
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	5.33	5.33	5.33	ChEMBL
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	5.0	5.22	5.55	PDSP Ki database
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	8.27	8.27	8.27	Drug Central
5-HT_1B	5HT1B	Mouse	5-Hydroxytryptamine	A	pKi	8.3	8.3	8.3	Guide to Pharmacology
5-HT_1B	5HT1B	Mouse	5-Hydroxytryptamine	A	pKi	8.08	8.08	8.08	Drug Central
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	6.4	6.53	6.66	PDSP Ki database
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	8.16	8.16	8.16	Drug Central
5-HT_1D	5HT1D	Rat	5-Hydroxytryptamine	A	pKi	7.52	7.52	7.52	PDSP Ki database
5-HT_1D	F1MMU1	Bovine	5-Hydroxytryptamine	A	pKi	6.32	6.37	6.4	PDSP Ki database
5-HT_1F	5HT1F	Human	5-Hydroxytryptamine	A	pKi	7.9	7.9	7.9	PDSP Ki database
5-HT_1F	5HT1F	Human	5-Hydroxytryptamine	A	pKi	8.09	8.09	8.09	Drug Central
5-HT_1F	5HT1F	Mouse	5-Hydroxytryptamine	A	pKi	7.0	7.0	7.0	PDSP Ki database
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	7.57	8.43	9.3	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	7.7	8.65	9.6	Guide to Pharmacology
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	7.25	8.18	8.8	PDSP Ki database
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	8.09	8.09	8.09	Drug Central
5-HT_2A	5HT2A	Rat	5-Hydroxytryptamine	A	pKi	7.79	8.44	9.26	PDSP Ki database
5-HT_2A	5HT2A	Rat	5-Hydroxytryptamine	A	pKi	8.4	8.7	9.0	Guide to Pharmacology
5-HT_2A	5HT2A	Rat	5-Hydroxytryptamine	A	pKi	8.05	8.05	8.05	Drug Central
5-HT_2A	5HT2A	Bovine	5-Hydroxytryptamine	A	pKi	8.17	8.17	8.17	PDSP Ki database
5-HT_2A	5HT2A	Pig	5-Hydroxytryptamine	A	pKi	7.44	7.44	7.44	PDSP Ki database
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	7.9	8.35	8.8	Guide to Pharmacology
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	8.33	8.33	8.33	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	7.7	8.12	8.8	PDSP Ki database
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	8.09	8.09	8.09	Drug Central
5-HT_2B	5HT2B	Rat	5-Hydroxytryptamine	A	pKi	7.3	7.3	7.3	Guide to Pharmacology
5-HT_2B	5HT2B	Rat	5-Hydroxytryptamine	A	pKi	6.7	7.17	7.3	PDSP Ki database
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	8.0	8.46	9.22	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	8.3	8.75	9.2	Guide to Pharmacology
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	8.18	8.53	9.2	PDSP Ki database
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	8.07	8.07	8.07	Drug Central
5-HT_2C	5HT2C	Dog	5-Hydroxytryptamine	A	pKi	8.55	8.55	8.55	PDSP Ki database
5-HT_2C	5HT2C	Rat	5-Hydroxytryptamine	A	pKi	8.8	9.1	9.4	Guide to Pharmacology
5-HT_2C	5HT2C	Rat	5-Hydroxytryptamine	A	pKi	8.85	8.85	8.85	ChEMBL
5-HT_2C	5HT2C	Rat	5-Hydroxytryptamine	A	pKi	7.96	8.62	9.4	PDSP Ki database
5-HT_2C	5HT2C	Rat	5-Hydroxytryptamine	A	pKi	8.05	8.05	8.05	Drug Central
5-HT_2C	5HT2C	Mouse	5-Hydroxytryptamine	A	pKi	8.62	8.62	8.62	PDSP Ki database
5-HT_2C	K7GSR7	Pig	5-Hydroxytryptamine	A	pKi	5.9	7.91	8.41	PDSP Ki database
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	6.9	7.1	7.3	Guide to Pharmacology
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	7.26	7.33	7.4	ChEMBL
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	7.09	7.2	7.26	PDSP Ki database
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	8.14	8.14	8.14	Drug Central
5-HT₆	5HT6R	Rat	5-Hydroxytryptamine	A	pKi	6.9	7.15	7.4	Guide to Pharmacology
5-HT₆	5HT6R	Rat	5-Hydroxytryptamine	A	pKi	6.91	7.29	7.42	PDSP Ki database
5-HT₆	5HT6R	Rat	5-Hydroxytryptamine	A	pKi	8.13	8.13	8.13	Drug Central
5-HT₆	5HT6R	Mouse	5-Hydroxytryptamine	A	pKi	7.0	7.73	8.49	PDSP Ki database
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pKi	5.1	6.52	7.25	ChEMBL
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pKi	7.3	7.45	7.6	Guide to Pharmacology
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pKi	5.1	6.17	7.25	PDSP Ki database
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pKi	8.15	8.15	8.15	Drug Central
5-HT₇	5HT7R	Mouse	5-Hydroxytryptamine	A	pKi	7.0	7.0	7.0	Guide to Pharmacology
5-HT₇	5HT7R	Mouse	5-Hydroxytryptamine	A	pKi	7.0	7.0	7.0	PDSP Ki database
5-HT₇	5HT7R	Mouse	5-Hydroxytryptamine	A	pKi	8.15	8.15	8.15	Drug Central
5-HT₇	5HT7R	Guinea pig	5-Hydroxytryptamine	A	pKi	6.18	6.57	6.97	PDSP Ki database
5-HT₇	5HT7R	Rat	5-Hydroxytryptamine	A	pKi	7.0	7.2	7.4	Guide to Pharmacology
5-HT₇	5HT7R	Rat	5-Hydroxytryptamine	A	pKi	7.0	7.1	7.2	ChEMBL
5-HT₇	5HT7R	Rat	5-Hydroxytryptamine	A	pKi	5.0	6.89	7.43	PDSP Ki database
5-HT₇	5HT7R	Rat	5-Hydroxytryptamine	A	pKi	8.14	8.14	8.14	Drug Central
D₁	DRD1	Human	Dopamine	A	pKi	6.57	6.57	6.57	ChEMBL
D₁	DRD1	Human	Dopamine	A	pKi	5.85	6.11	6.37	PDSP Ki database
D₁	DRD1	Human	Dopamine	A	pKi	8.22	8.22	8.22	Drug Central
D₁	DRD1	Bovine	Dopamine	A	pKi	5.6	6.05	6.5	PDSP Ki database
D₁	DRD1	Rat	Dopamine	A	pKi	5.85	5.85	5.85	ChEMBL
D₁	DRD1	Rat	Dopamine	A	pKi	8.23	8.23	8.23	Drug Central
D₂	DRD2	Rat	Dopamine	A	pKi	6.0	6.04	6.08	ChEMBL
D₂	DRD2	Human	Dopamine	A	pKi	5.66	5.66	5.66	ChEMBL
D₂	DRD2	Human	Dopamine	A	pKi	8.25	8.25	8.25	Drug Central
D₂	DRD2	Human	Dopamine	A	pKi	5.57	5.71	5.89	PDSP Ki database
D₂	DRD2	Bovine	Dopamine	A	pKi	6.21	6.21	6.21	PDSP Ki database
D₂	DRD2	Rat	Dopamine	A	pKi	5.0	5.66	6.17	PDSP Ki database
D₂	DRD2	Rat	Dopamine	A	pKi	8.22	8.22	8.22	Drug Central
D₃	DRD3	Human	Dopamine	A	pKi	5.55	5.55	5.55	ChEMBL
D₃	DRD3	Human	Dopamine	A	pKi	5.55	5.55	5.55	PDSP Ki database
D₃	DRD3	Human	Dopamine	A	pKi	8.26	8.26	8.26	Drug Central
D₃	DRD3	Rat	Dopamine	A	pKi	5.82	5.82	5.82	ChEMBL
D₃	DRD3	Rat	Dopamine	A	pKi	8.24	8.24	8.24	Drug Central
H₁	HRH1	Guinea pig	Histamine	A	pKi	9.07	9.07	9.07	ChEMBL
H₁	HRH1	Guinea pig	Histamine	A	pKi	8.04	8.04	8.04	Drug Central
H₁	HRH1	Guinea pig	Histamine	A	pKi	8.38	8.38	8.38	PDSP Ki database
H₁	HRH1	Human	Histamine	A	pKi	8.77	9.27	9.76	ChEMBL
H₁	HRH1	Human	Histamine	A	pKi	5.0	8.43	9.52	PDSP Ki database
H₁	HRH1	Human	Histamine	A	pKi	8.03	8.03	8.03	Drug Central
H₁	HRH1	Rat	Histamine	A	pKi	8.39	8.71	9.0	PDSP Ki database
H₂	HRH2	Human	Histamine	A	pKi	6.0	6.0	6.0	ChEMBL
H₂	HRH2	Human	Histamine	A	pKi	8.22	8.22	8.22	Drug Central
H₄	HRH4	Human	Histamine	A	pKi	6.12	6.12	6.12	PDSP Ki database
M₁	ACM1	Human	Acetylcholine (muscarinic)	A	pKi	6.46	6.46	6.46	ChEMBL
M₁	ACM1	Human	Acetylcholine (muscarinic)	A	pKi	8.19	8.19	8.19	Drug Central
M₂	ACM2	Human	Acetylcholine (muscarinic)	A	pKi	6.42	6.42	6.42	ChEMBL
M₂	ACM2	Human	Acetylcholine (muscarinic)	A	pKi	8.19	8.19	8.19	Drug Central
M₃	ACM3	Human	Acetylcholine (muscarinic)	A	pKi	6.53	6.53	6.53	ChEMBL
M₃	ACM3	Human	Acetylcholine (muscarinic)	A	pKi	8.19	8.19	8.19	Drug Central
M₄	ACM4	Human	Acetylcholine (muscarinic)	A	pKi	6.54	6.54	6.54	ChEMBL
M₄	ACM4	Human	Acetylcholine (muscarinic)	A	pKi	8.18	8.18	8.18	Drug Central
M₅	ACM5	Human	Acetylcholine (muscarinic)	A	pKi	6.64	6.64	6.64	ChEMBL
M₅	ACM5	Human	Acetylcholine (muscarinic)	A	pKi	8.18	8.18	8.18	Drug Central
α_1A	ADA1A	Bovine	Adrenoceptors	A	pKi	7.37	7.37	7.37	ChEMBL
α_1A	ADA1A	Rat	Adrenoceptors	A	pKi	7.04	7.04	7.04	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pKd	6.6	6.6	6.6	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pKi	7.6	7.6	7.6	Guide to Pharmacology
α_1A	ADA1A	Bovine	Adrenoceptors	A	pKi	8.13	8.13	8.13	Drug Central
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	7.4	7.4	7.4	Guide to Pharmacology
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	8.13	8.13	8.13	Drug Central
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	7.18	7.18	7.18	ChEMBL
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	8.14	8.14	8.14	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	7.5	7.5	7.5	Guide to Pharmacology
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	7.39	7.39	7.39	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.12	8.12	8.12	Drug Central
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	7.8	8.06	8.32	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	7.34	7.98	8.32	PDSP Ki database
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.08	8.08	8.08	Drug Central
α_2A	ADA2A	Bovine	Adrenoceptors	A	pKi	7.77	7.77	7.77	ChEMBL
α_2A	ADA2A	Bovine	Adrenoceptors	A	pKi	8.11	8.11	8.11	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	7.62	7.62	7.62	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	7.57	7.57	7.57	PDSP Ki database
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.12	8.12	8.12	Drug Central
α_2B	ADA2B	Rat	Adrenoceptors	A	pKi	7.34	7.59	7.85	PDSP Ki database
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	7.58	8.0	8.42	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	6.58	7.76	8.42	PDSP Ki database
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	8.07	8.07	8.07	Drug Central
α_2C	ADA2C	North American opossum	Adrenoceptors	A	pKi	6.72	7.54	8.35	PDSP Ki database

Showing 1 to 126 of 126 entries

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Receptor					Activity				Source
GTP No matches found	Uniprot No matches found	Species No matches found	Family No matches found	Class No matches found	Type No matches found	Min	Avg	Max	Database No matches found
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pIC50	6.4	6.4	6.4	ChEMBL
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pIC50	6.06	6.06	6.06	ChEMBL
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pIC50	6.42	6.42	6.42	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pIC50	7.68	8.14	8.75	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pIC50	8.14	8.14	8.14	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pIC50	8.13	8.54	8.94	ChEMBL
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pIC50	7.07	7.07	7.07	ChEMBL
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pIC50	6.94	6.94	6.94	ChEMBL
D₁	DRD1	Human	Dopamine	A	pIC50	6.26	6.26	6.26	ChEMBL
D₂	DRD2	Rat	Dopamine	A	pIC50	5.45	5.45	5.45	ChEMBL
D₂	DRD2	Human	Dopamine	A	pIC50	5.15	5.15	5.15	ChEMBL
D₃	DRD3	Human	Dopamine	A	pIC50	5.41	5.41	5.41	ChEMBL
D₄	DRD4	Human	Dopamine	A	pIC50	5.48	5.48	5.48	ChEMBL
D₄	DRD4	Human	Dopamine	A	pIC50	8.26	8.26	8.26	Drug Central
H₁	HRH1	Human	Histamine	A	pIC50	8.47	8.64	8.82	ChEMBL
H₂	HRH2	Human	Histamine	A	pIC50	6.0	6.0	6.0	ChEMBL
H₄	HRH4	Human	Histamine	A	pEC50	8.21	8.21	8.21	Drug Central
LPA₁	LPAR1	Human	Lysophospholipid (LPA)	A	pIC50	7.0	7.0	7.0	Guide to Pharmacology
M₁	ACM1	Human	Acetylcholine (muscarinic)	A	pIC50	5.85	5.85	5.85	ChEMBL
M₂	ACM2	Human	Acetylcholine (muscarinic)	A	pIC50	5.97	5.97	5.97	ChEMBL
M₃	ACM3	Human	Acetylcholine (muscarinic)	A	pIC50	5.85	5.85	5.85	ChEMBL
M₄	ACM4	Human	Acetylcholine (muscarinic)	A	pIC50	5.68	5.68	5.68	ChEMBL
M₅	ACM5	Human	Acetylcholine (muscarinic)	A	pIC50	6.5	6.5	6.5	ChEMBL
M₅	ACM5	Rat	Acetylcholine (muscarinic)	A	pIC50	5.72	5.72	5.72	ChEMBL
M₅	ACM5	Rat	Acetylcholine (muscarinic)	A	pIC50	8.24	8.24	8.24	Drug Central
α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	6.65	8.4	10.15	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pIC50	6.39	6.39	6.39	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pIC50	8.19	8.19	8.19	Drug Central
α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	7.99	7.99	7.99	Drug Central
α_1B	ADA1B	Rat	Adrenoceptors	A	pIC50	6.92	6.92	6.92	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pIC50	7.08	7.08	7.08	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	7.37	7.53	7.68	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	7.28	7.28	7.28	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pIC50	6.75	7.16	7.37	ChEMBL

Showing 1 to 34 of 34 entries

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mianserin

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