MTEP


SMILES Cc1scc(n1)C#Cc1cccnc1
InChIKey NRBNGHCYDWUVLC-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 0
Molecular weight (Da) 200.0

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Ligand site mutations mGlu5

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu5 GRM5 Rat Metabotropic glutamate C pKi 7.38 7.7 7.92 ChEMBL
mGlu5 GRM5 Human Metabotropic glutamate C pKi 7.49 7.49 7.49 ChEMBL
mGlu5 GRM5 Human Metabotropic glutamate C pKi 7.8 7.8 7.8 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu5 GRM5 Rat Metabotropic glutamate C pIC50 6.96 7.71 8.3 ChEMBL
mGlu5 GRM5 Human Metabotropic glutamate C pIC50 6.33 7.55 8.3 ChEMBL